Carcinogenicity of deoxycholate, a secondary bile acid

Carol Bernstein, Hana Holubec, Achyut K Bhattacharyya, Huy Nguyen, Claire M. Payne, Beryl Zaitlin, Harris Bernstein

Research output: Contribution to journalArticle

146 Citations (Scopus)

Abstract

High dietary fat causes increased bile acid secretion into the gastrointestinal tract and is associated with colon cancer. Since the bile acid deoxycholic acid (DOC) is suggested to be important in colon cancer etiology, this study investigated whether DOC, at a high physiologic level, could be a colon carcinogen. Addition of 0.2% DOC for 8-10 months to the diet of 18 wild-type mice induced colonic tumors in 17 mice, including 10 with cancers. Addition of the antioxidant chlorogenic acid at 0.007% to the DOC-supplemented diet significantly reduced tumor formation. These results indicate that a high fat diet in humans, associated with increased risk of colon cancer, may have its carcinogenic potential mediated through the action of bile acids, and that some dietary anti-oxidants may ameliorate this carcinogenicity.

Original languageEnglish (US)
Pages (from-to)863-871
Number of pages9
JournalArchives of Toxicology
Volume85
Issue number8
DOIs
StatePublished - Aug 2011

Fingerprint

Deoxycholic Acid
Bile Acids and Salts
Nutrition
Colonic Neoplasms
Tumors
Diet
Chlorogenic Acid
Neoplasms
Dietary Fats
High Fat Diet
Oxidants
Carcinogens
Gastrointestinal Tract
Colon
Antioxidants
Fats

Keywords

  • Adenocarcinoma
  • Chlorogenic acid
  • Colon cancer
  • Deoxycholate

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Bernstein, C., Holubec, H., Bhattacharyya, A. K., Nguyen, H., Payne, C. M., Zaitlin, B., & Bernstein, H. (2011). Carcinogenicity of deoxycholate, a secondary bile acid. Archives of Toxicology, 85(8), 863-871. https://doi.org/10.1007/s00204-011-0648-7

Carcinogenicity of deoxycholate, a secondary bile acid. / Bernstein, Carol; Holubec, Hana; Bhattacharyya, Achyut K; Nguyen, Huy; Payne, Claire M.; Zaitlin, Beryl; Bernstein, Harris.

In: Archives of Toxicology, Vol. 85, No. 8, 08.2011, p. 863-871.

Research output: Contribution to journalArticle

Bernstein, C, Holubec, H, Bhattacharyya, AK, Nguyen, H, Payne, CM, Zaitlin, B & Bernstein, H 2011, 'Carcinogenicity of deoxycholate, a secondary bile acid', Archives of Toxicology, vol. 85, no. 8, pp. 863-871. https://doi.org/10.1007/s00204-011-0648-7
Bernstein, Carol ; Holubec, Hana ; Bhattacharyya, Achyut K ; Nguyen, Huy ; Payne, Claire M. ; Zaitlin, Beryl ; Bernstein, Harris. / Carcinogenicity of deoxycholate, a secondary bile acid. In: Archives of Toxicology. 2011 ; Vol. 85, No. 8. pp. 863-871.
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