Cardiac activation mapping using ultrasound current source density imaging (UCSDI)

Ragnar Olafsson, Russell S Witte, Congxian Jia, Sheng Wen Huang, Kang Kim, Matthew O'Donnell

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

We describe the first mapping of biological current in a live heart using ultrasound current source density imaging (UCSDI). Ablation procedures that treat severe heart arrhythmias require detailed maps of the cardiac activation wave. The conventional procedure is time-consuming and limited by its poor spatial resolution (5-10 mm). UCSDI can potentially improve on existing mapping procedures. It is based on a pressure-induced change in resistivity known as the acousto-electric (AE) effect, which is spatially confined to the ultrasound focus. Data from 2 experiments are presented. A 540 kHz ultrasonic transducer (f/# = 1, focal length = 90 mm, pulse repetition frequency = 1600 Hz) was scanned over an isolated rabbit heart perfused with an excitation-contraction decoupler to reduce motion significantly while retaining electric function. Tungsten electrodes inserted in the left ventricle recorded simultaneously the AE signal and the low-frequency electrocardiogram (ECG). UCSDI displayed spatial and temporal patterns consistent with the spreading activation wave. The propagation velocity estimated from UCSDI was 0.25 ± 0.05 mm/ms, comparable to the values obtained with the ECG signals. The maximum AE signal-to-noise ratio after filtering was 18 dB, with an equivalent detection threshold of 0.1 mA/ cm2. This study demonstrates that UCSDI is a potentially powerful technique for mapping current flow and biopotentials in the heart.

Original languageEnglish (US)
Article number4816064
Pages (from-to)565-574
Number of pages10
JournalIEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
Volume56
Issue number3
DOIs
StatePublished - Mar 2009

Fingerprint

Ultrasonics
Chemical activation
activation
Imaging techniques
electrocardiography
Electrocardiography
Ultrasonic transducers
arrhythmia
Ablation
propagation velocity
rabbits
Tungsten
retaining
Signal to noise ratio
ablation
contraction
repetition
transducers
tungsten
signal to noise ratios

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Acoustics and Ultrasonics
  • Instrumentation

Cite this

Cardiac activation mapping using ultrasound current source density imaging (UCSDI). / Olafsson, Ragnar; Witte, Russell S; Jia, Congxian; Huang, Sheng Wen; Kim, Kang; O'Donnell, Matthew.

In: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, Vol. 56, No. 3, 4816064, 03.2009, p. 565-574.

Research output: Contribution to journalArticle

Olafsson, Ragnar ; Witte, Russell S ; Jia, Congxian ; Huang, Sheng Wen ; Kim, Kang ; O'Donnell, Matthew. / Cardiac activation mapping using ultrasound current source density imaging (UCSDI). In: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control. 2009 ; Vol. 56, No. 3. pp. 565-574.
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