Cardiac Regeneration in the Human Left Ventricle After CorMatrix Implantation

Alice Ferng, Alana Connell, Martha Nunez, Kitsie Johnson, Beth Braunhut, Scott D Lick, Ankit Desai, Toshinobu Kazui, Raymond B Runyan, Zain I Khalpey

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

CorMatrix is an organic extracellular matrix (ECM) derived from porcine small intestine submucosa and is used for pericardial closure and cardiac tissue repair. During explantation of a HeartMate II (Thoratec Corp, Pleasanton, CA) left ventricular assist device (LVAD) because of infection, CorMatrix was used to repair the left ventricular apex and aorta. Three months later, a HeartWare HVAD (HeartWare International, Inc, Framingham, MA) was implanted for recurrent heart failure. Excised apical CorMatrix samples showed cardiac tissue remodeling with viable cardiomyoblasts similar to native myocardium. Excised CorMatrix from the aorta showed organization of collagen and elastin similar to native aortic tissue.

Original languageEnglish (US)
Pages (from-to)e239-e241
JournalAnnals of Thoracic Surgery
Volume104
Issue number3
DOIs
Publication statusPublished - Sep 1 2017

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ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

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