Cardiac titin: An adjustable multi-functional spring

Hendrikus "Henk" Granzier, Siegfried Labeit

Research output: Contribution to journalArticle

163 Citations (Scopus)

Abstract

The giant elastic protein titin contains a molecular spring segment that underlies the majority of myocardial passive stiffness. The mechanical characteristics of this spring may be tuned to match changing mechanical demands placed on muscle, using mechanisms that operate on different time scales and that include post-transcriptional and post-translational processes. Recent work also suggests that titin performs roles that go beyond passive stiffness generation. In contracting myocardium, titin may modulate actomyosin interaction by a titin-based alteration of the distance between myosin heads and actin. Furthermore, novel ligands have been identified that link titin to membrane channels, protein turnover and gene expression. This review highlights that titin is a versatile and adjustable spring with a range of important functions in passive and contracting myocardium.

Original languageEnglish (US)
Pages (from-to)335-342
Number of pages8
JournalJournal of Physiology
Volume541
Issue number2
DOIs
StatePublished - Jun 1 2002
Externally publishedYes

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Connectin
Myocardium
Actomyosin
Myosins
Ion Channels
Actins
Membrane Proteins
Ligands
Gene Expression
Muscles

ASJC Scopus subject areas

  • Physiology

Cite this

Cardiac titin : An adjustable multi-functional spring. / Granzier, Hendrikus "Henk"; Labeit, Siegfried.

In: Journal of Physiology, Vol. 541, No. 2, 01.06.2002, p. 335-342.

Research output: Contribution to journalArticle

Granzier, Hendrikus "Henk" ; Labeit, Siegfried. / Cardiac titin : An adjustable multi-functional spring. In: Journal of Physiology. 2002 ; Vol. 541, No. 2. pp. 335-342.
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