Cardiotoxic effects of chemotherapy: A review of both cytotoxic and molecular targeted oncology therapies and their effect on the cardiovascular system

Hani M. Babiker, Ali McBride, Michael Newton, Leigh M. Boehmer, Adrienne Goeller Drucker, Mollie Gowan, Manouchkathe Cassagnol, Todd D Camenisch, Faiz - Anwer, James M. Hollands

Research output: Contribution to journalReview article

25 Scopus citations

Abstract

Cardiotoxic effects of chemotherapy and targeted drugs are ubiquitous and challenging in the field of oncology therapeutics. The broad spectrum of toxicities ranging from ischemic, hypertensive, cardiomyopathic, and arrhythmic complications can present as a significant challenge for clinicians treating cancer patients. If early diagnosis and intervention of cardiotoxic complications is missed, this can lead to delay or abrogation of planned treatment, which can potentially culminate to significant morbidity due to not only the cardiotoxic complications but also the progression of cancer. Hence, full knowledge of cardiovascular complications of chemotherapeutic agents, essential diagnostics tests to order, and appropriate management is paramount to oncologist, oncology pharmacists, and scientific clinical investigators. The aforementioned is particularly true in the current oncology era of plenteous early clinical trials studying several pathway/molecular-targeting agents with an increased cardiotoxic potential and the rapid expedited approval of those drugs by the FDA. Herein, we present a review discussing cardiotoxic effects of drugs and guidelines for management of the toxicities to assist the medical field in general managing patients with cancer.

Original languageEnglish (US)
Pages (from-to)186-200
Number of pages15
JournalCritical Reviews in Oncology/Hematology
Volume126
DOIs
StatePublished - Jun 1 2018

Keywords

  • Adverse effects
  • Anthracyclines
  • Antineoplastics
  • Cardio-oncology
  • Chemotherapy
  • Heart failure
  • Molecular targeted therapies
  • Monoclonal antibodies
  • Patient safety
  • QTc prolongation
  • Taxanes
  • Tyrosine kinase inhibitors

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Geriatrics and Gerontology

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