A mouse model of long-term doxorubicin hydrochloride (Adriamycin) toxicity, which demonstrated significantly longer survival when carnitine is administered simultaneously with doxorubicin, was evaluated by electron microscopic and biochemical study of cardiac muscle to correlate ultrastructural and metabolic changes with survival. One hundred Balb/C mice were randomly divided into four groups: control, carnitine, doxorubicin-carnitine, and doxorubicin alone. Significantly improved survival occurred in the doxorubicin-carnitine group when compared with the group receiving doxorubicin alone, in two separate experiments. However, there were no statistically significant differences in cardiac ultrastructure, carnitine concentration, or palmitate oxidation rates between treatment and control groups. The results indicate that although the mouse is useful for study of survival related to doxorubicin toxicity and combination drug therapies, it does not seem to be suitable for evaluation of ultrastructural changes related to longterm doxorubicin cardiotoxicity.
|Original language||English (US)|
|Number of pages||5|
|Journal||Archives of Pathology and Laboratory Medicine|
|State||Published - Jan 1 1982|
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Medical Laboratory Technology