Cardiovascular abnormalities and arrhythmias in patients with Ondine's curse (congenital central hypoventilation) syndrome

Mohammad Reza Movahed, Mehrdad Jalili, Nafiz Kiciman

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations

Abstract

Patients with congenital central hypoventilation syndrome (CCHS) (Ondine's curse syndrome) have impaired autonomic control of ventilation with intact voluntary control of respiration. Autonomic dysfunction and cardiac abnormalities are common in CCHS. Bradyarrhythmias are life-threatening and often require pacemaker insertion. We presented a case of a patient with CCHS suffering from long sinus pauses requiring cardiac pacemaker insertion. Patients with CCHS are at risk for pulmonary hypertension and cor pulmonale secondary to chronic hypoxia. Diaphragmatic pacing has been beneficial in some patients with CCHS. In this article, we review concomitant cardiac abnormalities and the occurrence of bradyarrhythmias in patients with CCHS.

Original languageEnglish (US)
Pages (from-to)1226-1230
Number of pages5
JournalPACE - Pacing and Clinical Electrophysiology
Volume28
Issue number11
DOIs
StatePublished - Nov 1 2005
Externally publishedYes

Keywords

  • Bradyarrhythmias
  • Cardiac abnormalities
  • Congenital central hypoventilation syndrome
  • Ondine's curse
  • Pacemaker

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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