Cardiovascular and hemodynamic effect of polyethylene glycol in Rats

Seyed Ahmad Samsamshariat, Mehrnoosh Hashemzadeh, Zahra Samsamshariat, Mohammad R Movahed

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: Polyethylene Glycol (PEG) is a solvent and used in a wide range of biomedical applications. Many fatty-acid-based molecules cannot be administered without a solvent in vivo. PEG can be used to dissolve compounds to make them water soluble. However, the effect of PEG on the cardiovascular system has not been studied. In this study, we evaluated the effect of PEG on the cardiovascular system in rat models. Methods: Twenty male Sprague-Dawley rats weighing 250-300 g were used in this study. The control group (10 rats) were injected intraperitoneally with 0.5 ml of 5% D/W in normal saline and the second group (10 rats) with PEG 400, 2 ml/kg ip, twice a day for 1 week. After 4 weeks, the rats underwent general anesthesia and a 1.4 French ultra miniature pressure volume catheter (Millar catheter) was placed in the left ventricle via the right carotid artery to measure comprehensive hemodynamic data. The data were analyzed with PVAN pressure-volume analysis software. Results: All the systolic and diastolic parameters were similar in both groups except for the effective arterial elastance (Ea), which was decreased in the PEG group. There were no significant differences in maximum (dp/dtmax) and minimum (dp/dtmin) development of pressure stroke work, cardiac output, ejection fraction, end systolic volume (Ves), and end diastolic volume. Conclusions: We have demonstrated that PEG, as a solvent, decreases Ea in rats in comparison to a placebo. Therefore, PEG as a solvent should be used cautiously in the cardiovascular research.

Original languageEnglish (US)
Pages (from-to)70-72
Number of pages3
JournalCardiovascular Revascularization Medicine
Volume6
Issue number2
DOIs
StatePublished - Apr 2005
Externally publishedYes

Fingerprint

Hemodynamics
Cardiovascular System
Pressure
Catheters
Carotid Arteries
Cardiac Output
General Anesthesia
Heart Ventricles
Sprague Dawley Rats
Fatty Acids
Software
Stroke
Placebos
Control Groups
Water
Research

Keywords

  • Animal study
  • Cardiovascular
  • Hemodynamic
  • PEG
  • Polyethylene glycol
  • Rat

ASJC Scopus subject areas

  • Molecular Medicine
  • Cardiology and Cardiovascular Medicine
  • Surgery

Cite this

Cardiovascular and hemodynamic effect of polyethylene glycol in Rats. / Samsamshariat, Seyed Ahmad; Hashemzadeh, Mehrnoosh; Samsamshariat, Zahra; Movahed, Mohammad R.

In: Cardiovascular Revascularization Medicine, Vol. 6, No. 2, 04.2005, p. 70-72.

Research output: Contribution to journalArticle

Samsamshariat, Seyed Ahmad ; Hashemzadeh, Mehrnoosh ; Samsamshariat, Zahra ; Movahed, Mohammad R. / Cardiovascular and hemodynamic effect of polyethylene glycol in Rats. In: Cardiovascular Revascularization Medicine. 2005 ; Vol. 6, No. 2. pp. 70-72.
@article{8c5795c01fb44ab5aa9144939d8b29de,
title = "Cardiovascular and hemodynamic effect of polyethylene glycol in Rats",
abstract = "Background: Polyethylene Glycol (PEG) is a solvent and used in a wide range of biomedical applications. Many fatty-acid-based molecules cannot be administered without a solvent in vivo. PEG can be used to dissolve compounds to make them water soluble. However, the effect of PEG on the cardiovascular system has not been studied. In this study, we evaluated the effect of PEG on the cardiovascular system in rat models. Methods: Twenty male Sprague-Dawley rats weighing 250-300 g were used in this study. The control group (10 rats) were injected intraperitoneally with 0.5 ml of 5{\%} D/W in normal saline and the second group (10 rats) with PEG 400, 2 ml/kg ip, twice a day for 1 week. After 4 weeks, the rats underwent general anesthesia and a 1.4 French ultra miniature pressure volume catheter (Millar catheter) was placed in the left ventricle via the right carotid artery to measure comprehensive hemodynamic data. The data were analyzed with PVAN pressure-volume analysis software. Results: All the systolic and diastolic parameters were similar in both groups except for the effective arterial elastance (Ea), which was decreased in the PEG group. There were no significant differences in maximum (dp/dtmax) and minimum (dp/dtmin) development of pressure stroke work, cardiac output, ejection fraction, end systolic volume (Ves), and end diastolic volume. Conclusions: We have demonstrated that PEG, as a solvent, decreases Ea in rats in comparison to a placebo. Therefore, PEG as a solvent should be used cautiously in the cardiovascular research.",
keywords = "Animal study, Cardiovascular, Hemodynamic, PEG, Polyethylene glycol, Rat",
author = "Samsamshariat, {Seyed Ahmad} and Mehrnoosh Hashemzadeh and Zahra Samsamshariat and Movahed, {Mohammad R}",
year = "2005",
month = "4",
doi = "10.1016/j.carrev.2005.07.002",
language = "English (US)",
volume = "6",
pages = "70--72",
journal = "Cardiovascular Revascularization Medicine",
issn = "1553-8389",
publisher = "Elsevier Inc.",
number = "2",

}

TY - JOUR

T1 - Cardiovascular and hemodynamic effect of polyethylene glycol in Rats

AU - Samsamshariat, Seyed Ahmad

AU - Hashemzadeh, Mehrnoosh

AU - Samsamshariat, Zahra

AU - Movahed, Mohammad R

PY - 2005/4

Y1 - 2005/4

N2 - Background: Polyethylene Glycol (PEG) is a solvent and used in a wide range of biomedical applications. Many fatty-acid-based molecules cannot be administered without a solvent in vivo. PEG can be used to dissolve compounds to make them water soluble. However, the effect of PEG on the cardiovascular system has not been studied. In this study, we evaluated the effect of PEG on the cardiovascular system in rat models. Methods: Twenty male Sprague-Dawley rats weighing 250-300 g were used in this study. The control group (10 rats) were injected intraperitoneally with 0.5 ml of 5% D/W in normal saline and the second group (10 rats) with PEG 400, 2 ml/kg ip, twice a day for 1 week. After 4 weeks, the rats underwent general anesthesia and a 1.4 French ultra miniature pressure volume catheter (Millar catheter) was placed in the left ventricle via the right carotid artery to measure comprehensive hemodynamic data. The data were analyzed with PVAN pressure-volume analysis software. Results: All the systolic and diastolic parameters were similar in both groups except for the effective arterial elastance (Ea), which was decreased in the PEG group. There were no significant differences in maximum (dp/dtmax) and minimum (dp/dtmin) development of pressure stroke work, cardiac output, ejection fraction, end systolic volume (Ves), and end diastolic volume. Conclusions: We have demonstrated that PEG, as a solvent, decreases Ea in rats in comparison to a placebo. Therefore, PEG as a solvent should be used cautiously in the cardiovascular research.

AB - Background: Polyethylene Glycol (PEG) is a solvent and used in a wide range of biomedical applications. Many fatty-acid-based molecules cannot be administered without a solvent in vivo. PEG can be used to dissolve compounds to make them water soluble. However, the effect of PEG on the cardiovascular system has not been studied. In this study, we evaluated the effect of PEG on the cardiovascular system in rat models. Methods: Twenty male Sprague-Dawley rats weighing 250-300 g were used in this study. The control group (10 rats) were injected intraperitoneally with 0.5 ml of 5% D/W in normal saline and the second group (10 rats) with PEG 400, 2 ml/kg ip, twice a day for 1 week. After 4 weeks, the rats underwent general anesthesia and a 1.4 French ultra miniature pressure volume catheter (Millar catheter) was placed in the left ventricle via the right carotid artery to measure comprehensive hemodynamic data. The data were analyzed with PVAN pressure-volume analysis software. Results: All the systolic and diastolic parameters were similar in both groups except for the effective arterial elastance (Ea), which was decreased in the PEG group. There were no significant differences in maximum (dp/dtmax) and minimum (dp/dtmin) development of pressure stroke work, cardiac output, ejection fraction, end systolic volume (Ves), and end diastolic volume. Conclusions: We have demonstrated that PEG, as a solvent, decreases Ea in rats in comparison to a placebo. Therefore, PEG as a solvent should be used cautiously in the cardiovascular research.

KW - Animal study

KW - Cardiovascular

KW - Hemodynamic

KW - PEG

KW - Polyethylene glycol

KW - Rat

UR - http://www.scopus.com/inward/record.url?scp=26044449065&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=26044449065&partnerID=8YFLogxK

U2 - 10.1016/j.carrev.2005.07.002

DO - 10.1016/j.carrev.2005.07.002

M3 - Article

VL - 6

SP - 70

EP - 72

JO - Cardiovascular Revascularization Medicine

JF - Cardiovascular Revascularization Medicine

SN - 1553-8389

IS - 2

ER -