Cargo from tumor-expressed albumin inhibits T-cell activation and responses

Michael W. Graner, Anna Likhacheva, Jane Davis, Amy Raymond, Jared Brandenberger, Angela Romanoski, Sylvia Thompson, Emmanuel Akporiaye, Emmanuel Katsanis

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Abstract

In this study, we show that rodent albumin is expressed by and cell surface localized on at least some murine tumor cells. We have been able to purify this tumor-expressed albumin from in vivo grown tumor masses. The tumor-expressed albumin, unlike normal serum albumin purified from blood, is capable of inhibiting T-cell activation, proliferation, and function in both in vitro and in vivo settings. Tumor-expressed albumin does not appear to affect antigen processing or presentation by professional antigen-presenting cells. The activity appears to lie in relatively small, lipid-like moieties that are presumably cargo for tumor-expressed albumin, and that activity can be removed from the albumin by lipid removal or treatment with lipase. Thus, we herein report of a novel form of tumor-induced immune suppression attributable to lipid-like entities, cloaked by albumin produced by tumors.

Original languageEnglish (US)
Pages (from-to)8085-8092
Number of pages8
JournalCancer Research
Volume64
Issue number21
DOIs
StatePublished - Nov 1 2004

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ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Graner, M. W., Likhacheva, A., Davis, J., Raymond, A., Brandenberger, J., Romanoski, A., Thompson, S., Akporiaye, E., & Katsanis, E. (2004). Cargo from tumor-expressed albumin inhibits T-cell activation and responses. Cancer Research, 64(21), 8085-8092. https://doi.org/10.1158/0008-5472.CAN-04-1871