Carnelley's rule and the prediction of melting point

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Carnelley (1882) made some important and useful observations on the relationship between the arrangement of the atoms in a molecule and its melting point. According to Brown and Brown (2000. J Chem Ed 77:724-731), Carnelley's rule states "of two or more isometric compounds, those whose atoms are the more symmetrically and the more compactly arranged melt higher than those in which the atomic arrangement is asymmetrical or in the form of long chains." Carnelley's rule can best be understood and quantitated from the dependence of the entropy of melting upon molecular geometry.

Original languageEnglish (US)
Pages (from-to)2629-2634
Number of pages6
JournalJournal of Pharmaceutical Sciences
Volume103
Issue number9
DOIs
StatePublished - 2014

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Keywords

  • Computer-aided drug design
  • crystals
  • drug design
  • drug-like properties
  • molecular modeling
  • physical characterization
  • physicochemical properties
  • QSPR

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Medicine(all)

Cite this

Carnelley's rule and the prediction of melting point. / Yalkowsky, Samuel H.

In: Journal of Pharmaceutical Sciences, Vol. 103, No. 9, 2014, p. 2629-2634.

Research output: Contribution to journalArticle

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