Catalyst free, C-3 functionalization of imidazo[1,2-a]pyridines to rapidly access new chemical space for drug discovery efforts

Naresh Gunaganti; Anupreet Kharbanda; Naga Rajiv Lakkaniga; Lingtian Zhang; Rose Cooper; Hong Yu Li; Brendan Frett

doi:10.1039/C8CC07063F

Catalyst free, C-3 functionalization of imidazo[1,2-a]pyridines to rapidly access new chemical space for drug discovery efforts

Naresh Gunaganti, Anupreet Kharbanda, Naga Rajiv Lakkaniga, Lingtian Zhang, Rose Cooper, Hong Yu Li, Brendan Frett

Research output: Contribution to journal › Article

7 Citations (Scopus)

Abstract

Multicomponent reactions (MCRs) are robust tools for the rapid synthesis of complex, small molecule libraries for use in drug discovery and development. By utilizing MCR chemistry, we developed a protocol to functionalize the C-3 position of imidazo[1,2-a]pyridine through a three component, decarboxylation reaction involving imidazo[1,2-a]pyridine, glyoxalic acid, and boronic acid.

Original language	English (US)
Pages (from-to)	12954-12957
Number of pages	4
Journal	Chemical Communications
Volume	54
Issue number	92
DOIs	https://doi.org/10.1039/C8CC07063F
State	Published - Jan 1 2018
Externally published	Yes

Fingerprint

Pyridine

Boronic Acids

Catalysts

Acids

Molecules

Drug Discovery

imidazo(1,2-a)pyridine

Decarboxylation

glyoxylic acid

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

Cite this

Gunaganti, N., Kharbanda, A., Lakkaniga, N. R., Zhang, L., Cooper, R., Li, H. Y., & Frett, B. (2018). Catalyst free, C-3 functionalization of imidazo[1,2-a]pyridines to rapidly access new chemical space for drug discovery efforts. Chemical Communications, 54(92), 12954-12957. https://doi.org/10.1039/C8CC07063F

Catalyst free, C-3 functionalization of imidazo[1,2-a]pyridines to rapidly access new chemical space for drug discovery efforts. / Gunaganti, Naresh; Kharbanda, Anupreet; Lakkaniga, Naga Rajiv; Zhang, Lingtian; Cooper, Rose; Li, Hong Yu; Frett, Brendan.

In: Chemical Communications, Vol. 54, No. 92, 01.01.2018, p. 12954-12957.

Research output: Contribution to journal › Article

Gunaganti, N, Kharbanda, A, Lakkaniga, NR, Zhang, L, Cooper, R, Li, HY & Frett, B 2018, 'Catalyst free, C-3 functionalization of imidazo[1,2-a]pyridines to rapidly access new chemical space for drug discovery efforts', Chemical Communications, vol. 54, no. 92, pp. 12954-12957. https://doi.org/10.1039/C8CC07063F

Gunaganti N, Kharbanda A, Lakkaniga NR, Zhang L, Cooper R, Li HY et al. Catalyst free, C-3 functionalization of imidazo[1,2-a]pyridines to rapidly access new chemical space for drug discovery efforts. Chemical Communications. 2018 Jan 1;54(92):12954-12957. https://doi.org/10.1039/C8CC07063F

Gunaganti, Naresh ; Kharbanda, Anupreet ; Lakkaniga, Naga Rajiv ; Zhang, Lingtian ; Cooper, Rose ; Li, Hong Yu ; Frett, Brendan. / Catalyst free, C-3 functionalization of imidazo[1,2-a]pyridines to rapidly access new chemical space for drug discovery efforts. In: Chemical Communications. 2018 ; Vol. 54, No. 92. pp. 12954-12957.

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Access to Document

10.1039/C8CC07063F