Catalyst free, C-3 functionalization of imidazo[1,2-a]pyridines to rapidly access new chemical space for drug discovery efforts

Naresh Gunaganti, Anupreet Kharbanda, Naga Rajiv Lakkaniga, Lingtian Zhang, Rose Cooper, Hong Yu Li, Brendan Frett

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Multicomponent reactions (MCRs) are robust tools for the rapid synthesis of complex, small molecule libraries for use in drug discovery and development. By utilizing MCR chemistry, we developed a protocol to functionalize the C-3 position of imidazo[1,2-a]pyridine through a three component, decarboxylation reaction involving imidazo[1,2-a]pyridine, glyoxalic acid, and boronic acid.

Original languageEnglish (US)
Pages (from-to)12954-12957
Number of pages4
JournalChemical Communications
Volume54
Issue number92
DOIs
StatePublished - Jan 1 2018
Externally publishedYes

Fingerprint

Pyridine
Boronic Acids
Catalysts
Acids
Molecules
Drug Discovery
imidazo(1,2-a)pyridine
Decarboxylation
glyoxylic acid

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

Cite this

Catalyst free, C-3 functionalization of imidazo[1,2-a]pyridines to rapidly access new chemical space for drug discovery efforts. / Gunaganti, Naresh; Kharbanda, Anupreet; Lakkaniga, Naga Rajiv; Zhang, Lingtian; Cooper, Rose; Li, Hong Yu; Frett, Brendan.

In: Chemical Communications, Vol. 54, No. 92, 01.01.2018, p. 12954-12957.

Research output: Contribution to journalArticle

Gunaganti, Naresh ; Kharbanda, Anupreet ; Lakkaniga, Naga Rajiv ; Zhang, Lingtian ; Cooper, Rose ; Li, Hong Yu ; Frett, Brendan. / Catalyst free, C-3 functionalization of imidazo[1,2-a]pyridines to rapidly access new chemical space for drug discovery efforts. In: Chemical Communications. 2018 ; Vol. 54, No. 92. pp. 12954-12957.
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