Catalytic ring expansion adventures

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

This account summarizes the Njardarson group ring expansion journey from early vinyl oxirane explorations to the latest vinyl oxetane ring expansion discoveries. The evolution of the program and incredible success of Cu(hfacac)2 as catalyst is detailed. Application of these new ring expansion reactions to natural product, pharmaceutical and commodity chemical targets is discussed as well as our intriguing mechanistic journey and interesting entry into the world of chiral counterion catalysis.

Original languageEnglish (US)
Article numberST-2013-A0056-A
Pages (from-to)787-803
Number of pages17
JournalSynlett
Volume24
Issue number7
DOIs
StatePublished - 2013

Keywords

  • aziridines
  • catalysis
  • oxetanes
  • oxiranes
  • ring expansion
  • strained rings
  • thiiranes

ASJC Scopus subject areas

  • Organic Chemistry

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