Catheter based instrument for simultaneous OCT imaging and fluorescence spectroscopy

Francisco Guzman, Jennifer K Barton

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We have developed an imaging device that provides cross-sectional imaging as well as fluorescence spectroscopy. The first application of this device is to differentiate healthy arterial wall from atherosclerotic plaque. Optical coherence tomography (OCT) provides two-dimensional imaging. OCT images have an imaging length and depth of 1-2 millimeters and 15 micron resolution. Laser induced fluorescence (LW) spectroscopy provides histochemical information. Due to high absorption of excitation wavelengths the fluorescence spectra is integrated from tissue only 200 microns deep. The OCT portion of the device is based on a Michelson interferometer. A superluminescent diode provides light at 1300 nm with 49 nm spectral width, and a galvanometer mounted retroreflector allows the reference arm length to be modulated. A helium cadmium laser provides the excitation source with wavelengths of 325 and 442 nm. In one instrument design, a series of dichroic mirrors is used to combine light from the OCT and LIF systems. In another design, OCT, excitation and emission fibers are combined into the same custom-built catheter for the delivery and collection of light. Preliminary data show that OCT images and LIF spectra give complementary information from normal and atherosclerotic portions of arterial wall.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsW.T.W. Riese, K.E. Bartels, L.S. Bass, K.W. Gregory
Pages430-437
Number of pages8
Volume4609
DOIs
StatePublished - 2002
EventLasers in Surgery: Advanced Characterization, Therapeutics, and Systems XII - San Jose, CA, United States
Duration: Jan 19 2002Jan 22 2002

Other

OtherLasers in Surgery: Advanced Characterization, Therapeutics, and Systems XII
CountryUnited States
CitySan Jose, CA
Period1/19/021/22/02

Fingerprint

Catheters
Optical tomography
Fluorescence spectroscopy
tomography
Imaging techniques
fluorescence
laser induced fluorescence
spectroscopy
Galvanometers
excitation
retroreflectors
galvanometers
Michelson interferometers
Wavelength
Lasers
wavelengths
Cadmium
cadmium
Helium
delivery

Keywords

  • Aorta
  • Atheroselerosis
  • He:Cd laser
  • Optical coherence tomography
  • Vessel

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Guzman, F., & Barton, J. K. (2002). Catheter based instrument for simultaneous OCT imaging and fluorescence spectroscopy. In W. T. W. Riese, K. E. Bartels, L. S. Bass, & K. W. Gregory (Eds.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 4609, pp. 430-437) https://doi.org/10.1117/12.432074

Catheter based instrument for simultaneous OCT imaging and fluorescence spectroscopy. / Guzman, Francisco; Barton, Jennifer K.

Proceedings of SPIE - The International Society for Optical Engineering. ed. / W.T.W. Riese; K.E. Bartels; L.S. Bass; K.W. Gregory. Vol. 4609 2002. p. 430-437.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Guzman, F & Barton, JK 2002, Catheter based instrument for simultaneous OCT imaging and fluorescence spectroscopy. in WTW Riese, KE Bartels, LS Bass & KW Gregory (eds), Proceedings of SPIE - The International Society for Optical Engineering. vol. 4609, pp. 430-437, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XII, San Jose, CA, United States, 1/19/02. https://doi.org/10.1117/12.432074
Guzman F, Barton JK. Catheter based instrument for simultaneous OCT imaging and fluorescence spectroscopy. In Riese WTW, Bartels KE, Bass LS, Gregory KW, editors, Proceedings of SPIE - The International Society for Optical Engineering. Vol. 4609. 2002. p. 430-437 https://doi.org/10.1117/12.432074
Guzman, Francisco ; Barton, Jennifer K. / Catheter based instrument for simultaneous OCT imaging and fluorescence spectroscopy. Proceedings of SPIE - The International Society for Optical Engineering. editor / W.T.W. Riese ; K.E. Bartels ; L.S. Bass ; K.W. Gregory. Vol. 4609 2002. pp. 430-437
@inproceedings{78c064d93c384db096b2682ceec3abaf,
title = "Catheter based instrument for simultaneous OCT imaging and fluorescence spectroscopy",
abstract = "We have developed an imaging device that provides cross-sectional imaging as well as fluorescence spectroscopy. The first application of this device is to differentiate healthy arterial wall from atherosclerotic plaque. Optical coherence tomography (OCT) provides two-dimensional imaging. OCT images have an imaging length and depth of 1-2 millimeters and 15 micron resolution. Laser induced fluorescence (LW) spectroscopy provides histochemical information. Due to high absorption of excitation wavelengths the fluorescence spectra is integrated from tissue only 200 microns deep. The OCT portion of the device is based on a Michelson interferometer. A superluminescent diode provides light at 1300 nm with 49 nm spectral width, and a galvanometer mounted retroreflector allows the reference arm length to be modulated. A helium cadmium laser provides the excitation source with wavelengths of 325 and 442 nm. In one instrument design, a series of dichroic mirrors is used to combine light from the OCT and LIF systems. In another design, OCT, excitation and emission fibers are combined into the same custom-built catheter for the delivery and collection of light. Preliminary data show that OCT images and LIF spectra give complementary information from normal and atherosclerotic portions of arterial wall.",
keywords = "Aorta, Atheroselerosis, He:Cd laser, Optical coherence tomography, Vessel",
author = "Francisco Guzman and Barton, {Jennifer K}",
year = "2002",
doi = "10.1117/12.432074",
language = "English (US)",
volume = "4609",
pages = "430--437",
editor = "W.T.W. Riese and K.E. Bartels and L.S. Bass and K.W. Gregory",
booktitle = "Proceedings of SPIE - The International Society for Optical Engineering",

}

TY - GEN

T1 - Catheter based instrument for simultaneous OCT imaging and fluorescence spectroscopy

AU - Guzman, Francisco

AU - Barton, Jennifer K

PY - 2002

Y1 - 2002

N2 - We have developed an imaging device that provides cross-sectional imaging as well as fluorescence spectroscopy. The first application of this device is to differentiate healthy arterial wall from atherosclerotic plaque. Optical coherence tomography (OCT) provides two-dimensional imaging. OCT images have an imaging length and depth of 1-2 millimeters and 15 micron resolution. Laser induced fluorescence (LW) spectroscopy provides histochemical information. Due to high absorption of excitation wavelengths the fluorescence spectra is integrated from tissue only 200 microns deep. The OCT portion of the device is based on a Michelson interferometer. A superluminescent diode provides light at 1300 nm with 49 nm spectral width, and a galvanometer mounted retroreflector allows the reference arm length to be modulated. A helium cadmium laser provides the excitation source with wavelengths of 325 and 442 nm. In one instrument design, a series of dichroic mirrors is used to combine light from the OCT and LIF systems. In another design, OCT, excitation and emission fibers are combined into the same custom-built catheter for the delivery and collection of light. Preliminary data show that OCT images and LIF spectra give complementary information from normal and atherosclerotic portions of arterial wall.

AB - We have developed an imaging device that provides cross-sectional imaging as well as fluorescence spectroscopy. The first application of this device is to differentiate healthy arterial wall from atherosclerotic plaque. Optical coherence tomography (OCT) provides two-dimensional imaging. OCT images have an imaging length and depth of 1-2 millimeters and 15 micron resolution. Laser induced fluorescence (LW) spectroscopy provides histochemical information. Due to high absorption of excitation wavelengths the fluorescence spectra is integrated from tissue only 200 microns deep. The OCT portion of the device is based on a Michelson interferometer. A superluminescent diode provides light at 1300 nm with 49 nm spectral width, and a galvanometer mounted retroreflector allows the reference arm length to be modulated. A helium cadmium laser provides the excitation source with wavelengths of 325 and 442 nm. In one instrument design, a series of dichroic mirrors is used to combine light from the OCT and LIF systems. In another design, OCT, excitation and emission fibers are combined into the same custom-built catheter for the delivery and collection of light. Preliminary data show that OCT images and LIF spectra give complementary information from normal and atherosclerotic portions of arterial wall.

KW - Aorta

KW - Atheroselerosis

KW - He:Cd laser

KW - Optical coherence tomography

KW - Vessel

UR - http://www.scopus.com/inward/record.url?scp=0036401795&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036401795&partnerID=8YFLogxK

U2 - 10.1117/12.432074

DO - 10.1117/12.432074

M3 - Conference contribution

AN - SCOPUS:0036401795

VL - 4609

SP - 430

EP - 437

BT - Proceedings of SPIE - The International Society for Optical Engineering

A2 - Riese, W.T.W.

A2 - Bartels, K.E.

A2 - Bass, L.S.

A2 - Gregory, K.W.

ER -