Catheter-based systems with integrated stretchable sensors and conductors in cardiac electrophysiology

Stephen P. Lee, Lauren E. Klinker, Leon Ptaszek, John Work, Cliff Liu, Fernando Quivara, Chad Webb, Canan Dagdeviren, John A. Wright, Jeremy N. Ruskin, Marvin J Slepian, Yonggang Huang, Moussa Mansour, John A. Rogers, Roozbeh Ghaffari

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Established classes of high-performance electronics have driven advances in interventional biomedicine. However, the large size, planar geometry and stiff mechanical properties of standard conventional electronics employed in medical devices give rise to important integration challenges with soft biological tissue. Stretchable and flexible biointegrated electronics could improve treatment procedures across a broad range of applications, including cardiac, neural and endovascular therapies. Here we present novel mechanics, materials and integration strategies for this new class of bioelectronics onboard minimally invasive catheter based systems. Co-located arrays of sensors and actuators affixed to cardiac and angioplasty balloon catheters capture new sensory information during ablation procedures, offering physicians the ability to adjust placement and treatment intra-procedurally. New circuit topologies, enabled by stretchable electronics, also overcome long standing challenges associated with transmitting vast amounts of data through narrow catheter lumens, thus allowing for a large number of sensors to be multiplexed for mapping electrophysiological activity with high spatiotemporal resolution and with a minimal number of routing wires. We present representative examples that highlight the clinical significance of soft bio-integrated electronics, along with the mechanics and processes that enable this technology.

Original languageEnglish (US)
Article number7110430
Pages (from-to)682-689
Number of pages8
JournalProceedings of the IEEE
Volume103
Issue number4
DOIs
StatePublished - Apr 1 2015

Fingerprint

Catheters
Electronic equipment
Sensors
Mechanics
Flexible electronics
Electric network topology
Balloons
Ablation
Actuators
Wire
Tissue
Mechanical properties
Geometry
Cardiac Electrophysiology

Keywords

  • biomedical devices
  • biosensors
  • electrophysiology
  • Flexible electronics
  • microfabrication
  • semiconductors
  • vasculature

ASJC Scopus subject areas

  • Electrical and Electronic Engineering

Cite this

Lee, S. P., Klinker, L. E., Ptaszek, L., Work, J., Liu, C., Quivara, F., ... Ghaffari, R. (2015). Catheter-based systems with integrated stretchable sensors and conductors in cardiac electrophysiology. Proceedings of the IEEE, 103(4), 682-689. [7110430]. https://doi.org/10.1109/JPROC.2015.2401596

Catheter-based systems with integrated stretchable sensors and conductors in cardiac electrophysiology. / Lee, Stephen P.; Klinker, Lauren E.; Ptaszek, Leon; Work, John; Liu, Cliff; Quivara, Fernando; Webb, Chad; Dagdeviren, Canan; Wright, John A.; Ruskin, Jeremy N.; Slepian, Marvin J; Huang, Yonggang; Mansour, Moussa; Rogers, John A.; Ghaffari, Roozbeh.

In: Proceedings of the IEEE, Vol. 103, No. 4, 7110430, 01.04.2015, p. 682-689.

Research output: Contribution to journalArticle

Lee, SP, Klinker, LE, Ptaszek, L, Work, J, Liu, C, Quivara, F, Webb, C, Dagdeviren, C, Wright, JA, Ruskin, JN, Slepian, MJ, Huang, Y, Mansour, M, Rogers, JA & Ghaffari, R 2015, 'Catheter-based systems with integrated stretchable sensors and conductors in cardiac electrophysiology', Proceedings of the IEEE, vol. 103, no. 4, 7110430, pp. 682-689. https://doi.org/10.1109/JPROC.2015.2401596
Lee, Stephen P. ; Klinker, Lauren E. ; Ptaszek, Leon ; Work, John ; Liu, Cliff ; Quivara, Fernando ; Webb, Chad ; Dagdeviren, Canan ; Wright, John A. ; Ruskin, Jeremy N. ; Slepian, Marvin J ; Huang, Yonggang ; Mansour, Moussa ; Rogers, John A. ; Ghaffari, Roozbeh. / Catheter-based systems with integrated stretchable sensors and conductors in cardiac electrophysiology. In: Proceedings of the IEEE. 2015 ; Vol. 103, No. 4. pp. 682-689.
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