Causal links between plasma and CSF endorphin levels in stress

Vector-ARMA analysis

Daniel B. Carr, Kenneth J. Jones, Richard M. Bergland, Allan J Hamilton, Norman W. Kasting, John E. Fisher, Joseph B. Martin

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

To explore causal links between vital sign responses and immunoreactive beta-endorphin ("i-BE") rises in blood and CSF during ovine endotoxin stress, we analyzed concurrent i-BE levels in these two compartments by a "vector-ARMA" (=autoregressive moving average) method. This technique-widely used for modeling in other applications-has not to our knowledge been employed to study dynamic relationships of neuropeptides. Log-transformed i-BE levels were first "filtered" by repeated observations ANOVA to confirm significance of rises in both compartments. Next, vector-ARMA methodology was applied to derive an optimal causal model of vital sign changes and i-BE entry into plasma vs. CSF pools. The model indicated that reflux of i-BE from blood into CSF contributed to increases in CSF levels of this hormone. This novel application to neuroendocrinology of this approach illustrates its utility in evaluating changes in one or more neuropeptide levels in multiple compartments to indicate potentially causal relationships.

Original languageEnglish (US)
Pages (from-to)5-10
Number of pages6
JournalPeptides
Volume6
Issue numberSUPPL. 1
DOIs
StatePublished - 1985
Externally publishedYes

Fingerprint

Endorphins
Vital Signs
Neuropeptides
Blood
Neuroendocrinology
Plasmas
beta-Endorphin
Analysis of variance (ANOVA)
Endotoxins
Sheep
Analysis of Variance
Hormones

Keywords

  • Beta-endorphin
  • Causality
  • Endotoxin
  • Modeling
  • Opioid
  • Peptide
  • Stress

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Cellular and Molecular Neuroscience

Cite this

Carr, D. B., Jones, K. J., Bergland, R. M., Hamilton, A. J., Kasting, N. W., Fisher, J. E., & Martin, J. B. (1985). Causal links between plasma and CSF endorphin levels in stress: Vector-ARMA analysis. Peptides, 6(SUPPL. 1), 5-10. https://doi.org/10.1016/0196-9781(85)90004-X

Causal links between plasma and CSF endorphin levels in stress : Vector-ARMA analysis. / Carr, Daniel B.; Jones, Kenneth J.; Bergland, Richard M.; Hamilton, Allan J; Kasting, Norman W.; Fisher, John E.; Martin, Joseph B.

In: Peptides, Vol. 6, No. SUPPL. 1, 1985, p. 5-10.

Research output: Contribution to journalArticle

Carr, DB, Jones, KJ, Bergland, RM, Hamilton, AJ, Kasting, NW, Fisher, JE & Martin, JB 1985, 'Causal links between plasma and CSF endorphin levels in stress: Vector-ARMA analysis', Peptides, vol. 6, no. SUPPL. 1, pp. 5-10. https://doi.org/10.1016/0196-9781(85)90004-X
Carr, Daniel B. ; Jones, Kenneth J. ; Bergland, Richard M. ; Hamilton, Allan J ; Kasting, Norman W. ; Fisher, John E. ; Martin, Joseph B. / Causal links between plasma and CSF endorphin levels in stress : Vector-ARMA analysis. In: Peptides. 1985 ; Vol. 6, No. SUPPL. 1. pp. 5-10.
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