CC16 levels into adult life are associated with nitrogen dioxide exposure at birth

Paloma I. Beamer, Melissa Furlong, Nathan Lothrop, Stefano Guerra, Dean Billheimer, Debra A. Stern, Jing Zhai, Marilyn Halonen, Anne L. Wright, Fernando D. Martinez

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Rationale: Lung function and growth are adversely associated with nitrogen dioxide (NO2) exposure. Lower levels of circulating club cell secretory protein (CC16) in childhood are also associated with subsequent decreased lung function. NO2 exposure may induce epithelial damage in lungs and alter club cell proliferation and morphology. Objectives: To determine if increased ambient NO2 levels at participants' home addresses in early life were associated with decreased levels of CC16 from age 6 to 32 years. Methods: Participants were enrolled at birth in the Tucson Children's Respiratory Study and had circulating CC16 measured at least once between age 6 and 32. Linear mixed models were used to determine the association between estimated ambient NO2 exposure at participants' home address at birth or age 6 with CC16 levels from age 6 to 32. Measurements and Main Results: NO2 exposures at birth or age 6 were available for 777 children with one or more CC16 measurement. We found a negative association between NO2 exposure and CC16 levels, with a 4.7% (95% confidence interval, -8.6 to -0.7) decrease in CC16 levels from age 6 to 32 per interquartile range increase in NO2 exposure (6.0 ppb) at the participants' birth address. We observed modification by race (p interaction = 0.04), with stronger associations among participants with at least one black parent (-29.6% [95% confidence interval, -42.9% to -13.2%] per interquartile range). NO2 at participant's age 6 address was not significantly associated with CC16 levels (-1.9%; 95% confidence interval, -6.3 to 2.6). Conclusions: Higher exposure to NO2 at birth is associated with persistently low levels of CC16 from 6 to 32 years.

Original languageEnglish (US)
Pages (from-to)600-607
Number of pages8
JournalAmerican journal of respiratory and critical care medicine
Volume200
Issue number5
DOIs
StatePublished - Sep 1 2019

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Nitrogen Dioxide
Parturition
Confidence Intervals
Lung
Linear Models
Parents
Cell Proliferation
Growth
Proteins

Keywords

  • Air pollution
  • Biomarker
  • Club cell

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

Cite this

CC16 levels into adult life are associated with nitrogen dioxide exposure at birth. / Beamer, Paloma I.; Furlong, Melissa; Lothrop, Nathan; Guerra, Stefano; Billheimer, Dean; Stern, Debra A.; Zhai, Jing; Halonen, Marilyn; Wright, Anne L.; Martinez, Fernando D.

In: American journal of respiratory and critical care medicine, Vol. 200, No. 5, 01.09.2019, p. 600-607.

Research output: Contribution to journalArticle

Beamer, Paloma I. ; Furlong, Melissa ; Lothrop, Nathan ; Guerra, Stefano ; Billheimer, Dean ; Stern, Debra A. ; Zhai, Jing ; Halonen, Marilyn ; Wright, Anne L. ; Martinez, Fernando D. / CC16 levels into adult life are associated with nitrogen dioxide exposure at birth. In: American journal of respiratory and critical care medicine. 2019 ; Vol. 200, No. 5. pp. 600-607.
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title = "CC16 levels into adult life are associated with nitrogen dioxide exposure at birth",
abstract = "Rationale: Lung function and growth are adversely associated with nitrogen dioxide (NO2) exposure. Lower levels of circulating club cell secretory protein (CC16) in childhood are also associated with subsequent decreased lung function. NO2 exposure may induce epithelial damage in lungs and alter club cell proliferation and morphology. Objectives: To determine if increased ambient NO2 levels at participants' home addresses in early life were associated with decreased levels of CC16 from age 6 to 32 years. Methods: Participants were enrolled at birth in the Tucson Children's Respiratory Study and had circulating CC16 measured at least once between age 6 and 32. Linear mixed models were used to determine the association between estimated ambient NO2 exposure at participants' home address at birth or age 6 with CC16 levels from age 6 to 32. Measurements and Main Results: NO2 exposures at birth or age 6 were available for 777 children with one or more CC16 measurement. We found a negative association between NO2 exposure and CC16 levels, with a 4.7{\%} (95{\%} confidence interval, -8.6 to -0.7) decrease in CC16 levels from age 6 to 32 per interquartile range increase in NO2 exposure (6.0 ppb) at the participants' birth address. We observed modification by race (p interaction = 0.04), with stronger associations among participants with at least one black parent (-29.6{\%} [95{\%} confidence interval, -42.9{\%} to -13.2{\%}] per interquartile range). NO2 at participant's age 6 address was not significantly associated with CC16 levels (-1.9{\%}; 95{\%} confidence interval, -6.3 to 2.6). Conclusions: Higher exposure to NO2 at birth is associated with persistently low levels of CC16 from 6 to 32 years.",
keywords = "Air pollution, Biomarker, Club cell",
author = "Beamer, {Paloma I.} and Melissa Furlong and Nathan Lothrop and Stefano Guerra and Dean Billheimer and Stern, {Debra A.} and Jing Zhai and Marilyn Halonen and Wright, {Anne L.} and Martinez, {Fernando D.}",
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T1 - CC16 levels into adult life are associated with nitrogen dioxide exposure at birth

AU - Beamer, Paloma I.

AU - Furlong, Melissa

AU - Lothrop, Nathan

AU - Guerra, Stefano

AU - Billheimer, Dean

AU - Stern, Debra A.

AU - Zhai, Jing

AU - Halonen, Marilyn

AU - Wright, Anne L.

AU - Martinez, Fernando D.

PY - 2019/9/1

Y1 - 2019/9/1

N2 - Rationale: Lung function and growth are adversely associated with nitrogen dioxide (NO2) exposure. Lower levels of circulating club cell secretory protein (CC16) in childhood are also associated with subsequent decreased lung function. NO2 exposure may induce epithelial damage in lungs and alter club cell proliferation and morphology. Objectives: To determine if increased ambient NO2 levels at participants' home addresses in early life were associated with decreased levels of CC16 from age 6 to 32 years. Methods: Participants were enrolled at birth in the Tucson Children's Respiratory Study and had circulating CC16 measured at least once between age 6 and 32. Linear mixed models were used to determine the association between estimated ambient NO2 exposure at participants' home address at birth or age 6 with CC16 levels from age 6 to 32. Measurements and Main Results: NO2 exposures at birth or age 6 were available for 777 children with one or more CC16 measurement. We found a negative association between NO2 exposure and CC16 levels, with a 4.7% (95% confidence interval, -8.6 to -0.7) decrease in CC16 levels from age 6 to 32 per interquartile range increase in NO2 exposure (6.0 ppb) at the participants' birth address. We observed modification by race (p interaction = 0.04), with stronger associations among participants with at least one black parent (-29.6% [95% confidence interval, -42.9% to -13.2%] per interquartile range). NO2 at participant's age 6 address was not significantly associated with CC16 levels (-1.9%; 95% confidence interval, -6.3 to 2.6). Conclusions: Higher exposure to NO2 at birth is associated with persistently low levels of CC16 from 6 to 32 years.

AB - Rationale: Lung function and growth are adversely associated with nitrogen dioxide (NO2) exposure. Lower levels of circulating club cell secretory protein (CC16) in childhood are also associated with subsequent decreased lung function. NO2 exposure may induce epithelial damage in lungs and alter club cell proliferation and morphology. Objectives: To determine if increased ambient NO2 levels at participants' home addresses in early life were associated with decreased levels of CC16 from age 6 to 32 years. Methods: Participants were enrolled at birth in the Tucson Children's Respiratory Study and had circulating CC16 measured at least once between age 6 and 32. Linear mixed models were used to determine the association between estimated ambient NO2 exposure at participants' home address at birth or age 6 with CC16 levels from age 6 to 32. Measurements and Main Results: NO2 exposures at birth or age 6 were available for 777 children with one or more CC16 measurement. We found a negative association between NO2 exposure and CC16 levels, with a 4.7% (95% confidence interval, -8.6 to -0.7) decrease in CC16 levels from age 6 to 32 per interquartile range increase in NO2 exposure (6.0 ppb) at the participants' birth address. We observed modification by race (p interaction = 0.04), with stronger associations among participants with at least one black parent (-29.6% [95% confidence interval, -42.9% to -13.2%] per interquartile range). NO2 at participant's age 6 address was not significantly associated with CC16 levels (-1.9%; 95% confidence interval, -6.3 to 2.6). Conclusions: Higher exposure to NO2 at birth is associated with persistently low levels of CC16 from 6 to 32 years.

KW - Air pollution

KW - Biomarker

KW - Club cell

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U2 - 10.1164/rccm.201808-1488OC

DO - 10.1164/rccm.201808-1488OC

M3 - Article

C2 - 30789752

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VL - 200

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JO - American Journal of Respiratory and Critical Care Medicine

JF - American Journal of Respiratory and Critical Care Medicine

SN - 1073-449X

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