CD14 and toll-like receptors

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

In the last decade, extraordinary progress has been made in characterizing at the molecular and genetic level the components of the human immune system that mediate the innate response to microbial organisms and products. Among these components are CD14 and the family of toll-like receptors (TLRs). CD14 interacts with TLR4 and at least another protein, MD-2, to form a receptor complex with specificity for endotoxin [lipopolysaccharide, (LPS)-a component of gram-negative bacteria]. The TLR family includes at least 10 transmembrane proteins (TLR1-10) that recognize a large variety of viral and bacterial constituents and are essential for an effective host defense against microbes. The sequencing of the human genome has revealed substantial interindividual variation in the genes encoding CD14 and TLRs, and functional studies have shown that some of these genetic variants have a significant impact on gene expression and/or protein function (1).

Original languageEnglish (US)
Title of host publicationGenetics of Asthma and Chronic Obstructive Pulmonary Disease
PublisherCRC Press
Pages333-356
Number of pages24
ISBN (Electronic)9781420019728
ISBN (Print)9780849369667
StatePublished - Jan 1 2006

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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    Guerra, S., & Martinez, F. D. (2006). CD14 and toll-like receptors. In Genetics of Asthma and Chronic Obstructive Pulmonary Disease (pp. 333-356). CRC Press.