CD44 Promotes Epithelial Mammary Gland Development and Exhibits Altered Localization during Cancer Progression

Jeanne M V Louderbough, Jessie A. Brown, Raymond B Nagle, Joyce Schroeder

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The basal cell layer has emerged as a critical player in cancer progression, and understanding the molecular contribution of specific cell types is important in treatment and prevention. The adhesion receptor CD44, which mediates epithelial-stromal and cell-cell interactions, has been shown to both promote and suppress tumor progression. To better understand the normal function of CD44, we have investigated its role in mouse mammary gland development and its expression in human breast and prostate cancer. We have found that CD44 is expressed in the myoepithelium of the developing mammary gland and modulates ductal development of FVB/N mice. The loss of CD44 results in defective luminal-myoepithelial cell-cell adhesion and promotes the mixing of luminal and myoepithelial layers, disrupting epithelial bilayer organization, and CD44-null mice experience delayed ductal outgrowth and impaired terminal end bud formation. The myoepithelial expression of CD44 is also relevant to its expression in cancer, as CD44 is expressed in the basal cells of early-stage breast and prostate cancer but exhibits altered localization with increasing tumorigenicity and is strongly expressed by tumor epithelium.

Original languageEnglish (US)
Pages (from-to)771-781
Number of pages11
JournalGenes and Cancer
Volume2
Issue number8
DOIs
StatePublished - Aug 2011

Fingerprint

Human Mammary Glands
Neoplasms
Prostatic Neoplasms
Breast Neoplasms
Stromal Cells
Cell Adhesion
Cell Communication
Epithelium
Epithelial Cells

Keywords

  • basal cell
  • breast cancer
  • CD44
  • cell adhesion
  • mammary gland development
  • myoepithelial cell
  • prostate cancer

ASJC Scopus subject areas

  • Cancer Research
  • Genetics

Cite this

CD44 Promotes Epithelial Mammary Gland Development and Exhibits Altered Localization during Cancer Progression. / Louderbough, Jeanne M V; Brown, Jessie A.; Nagle, Raymond B; Schroeder, Joyce.

In: Genes and Cancer, Vol. 2, No. 8, 08.2011, p. 771-781.

Research output: Contribution to journalArticle

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