Celiac disease: The search for adjunctive or alternative therapies

Kareem Hassan, Hesham A-Kader

Research output: Contribution to journalReview article

Abstract

Celiac disease is a widespread disorder caused by intolerance to gluten, a common protein in food. Currently, a life-long gluten-free diet is the only available treatment for patients with celiac disease. However, adherence to gluten-free diet is difficult due to the widespread use of wheat-derived gluten in the food industry. Therefore, there is a pressing need for the development of novel non-dietary therapies. In this article, we will review several promising strategies focusing on reducing gluten immunogenicity or sequestering to gluten prevent its uptake by the intestinal epithelium. Other possible treatment strategies that will be reviewed include the suppression of the adaptive immune response, permeability modulation and the use of systemic T-cell or cytokine blockers.

Original languageEnglish (US)
Pages (from-to)313-321
Number of pages9
JournalExpert Review of Gastroenterology and Hepatology
Volume8
Issue number3
DOIs
StatePublished - Mar 1 2014

Keywords

  • celiac
  • gluten
  • gluten protease
  • gluten sequestrant
  • immune modulation
  • novel
  • therapy

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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