Cell-cell interactions in regulating lung function

Scott A Boitano, Zeenat Safdar, Donald G. Welsh, Jahar Bhattacharya, Michael Koval

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Tight junction barrier formation and gap junctional communication are two functions directly attributable to cell-cell contact sites. Epithelial and endothelial tight junctions are critical elements of the permeability barrier required to maintain discrete compartments in the lung. On the other hand, gap junctions enable a tissue to act as a cohesive unit by permitting metabolic coupling and enabling the direct transmission of small cytosolic signaling molecules from one cell to another. These components do not act in isolation since other junctional elements, such as adherens junctions, help regulate barrier function and gap junctional communication. Some fundamental elements related to regulation of pulmonary barrier function and gap junctional communication were presented in a Featured Topic session at the 2004 Experimental Biology Conference in Washington, DC, and are reviewed in this summary.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Lung Cellular and Molecular Physiology
Volume287
Issue number3 31-3
DOIs
StatePublished - Sep 2004

Fingerprint

Cell Communication
Tight Junctions
Lung
Adherens Junctions
Gap Junctions
Permeability

Keywords

  • Cadherin
  • Calcium
  • Claudin
  • Connexin
  • Gap junction
  • Tight junction

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Cell Biology
  • Physiology

Cite this

Cell-cell interactions in regulating lung function. / Boitano, Scott A; Safdar, Zeenat; Welsh, Donald G.; Bhattacharya, Jahar; Koval, Michael.

In: American Journal of Physiology - Lung Cellular and Molecular Physiology, Vol. 287, No. 3 31-3, 09.2004.

Research output: Contribution to journalArticle

Boitano, Scott A ; Safdar, Zeenat ; Welsh, Donald G. ; Bhattacharya, Jahar ; Koval, Michael. / Cell-cell interactions in regulating lung function. In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 2004 ; Vol. 287, No. 3 31-3.
@article{57f9496f61ce448d9da2f264d76d6ccf,
title = "Cell-cell interactions in regulating lung function",
abstract = "Tight junction barrier formation and gap junctional communication are two functions directly attributable to cell-cell contact sites. Epithelial and endothelial tight junctions are critical elements of the permeability barrier required to maintain discrete compartments in the lung. On the other hand, gap junctions enable a tissue to act as a cohesive unit by permitting metabolic coupling and enabling the direct transmission of small cytosolic signaling molecules from one cell to another. These components do not act in isolation since other junctional elements, such as adherens junctions, help regulate barrier function and gap junctional communication. Some fundamental elements related to regulation of pulmonary barrier function and gap junctional communication were presented in a Featured Topic session at the 2004 Experimental Biology Conference in Washington, DC, and are reviewed in this summary.",
keywords = "Cadherin, Calcium, Claudin, Connexin, Gap junction, Tight junction",
author = "Boitano, {Scott A} and Zeenat Safdar and Welsh, {Donald G.} and Jahar Bhattacharya and Michael Koval",
year = "2004",
month = "9",
doi = "10.1152/ajplung.00172.2004",
language = "English (US)",
volume = "287",
journal = "American Journal of Physiology",
issn = "0363-6143",
publisher = "American Physiological Society",
number = "3 31-3",

}

TY - JOUR

T1 - Cell-cell interactions in regulating lung function

AU - Boitano, Scott A

AU - Safdar, Zeenat

AU - Welsh, Donald G.

AU - Bhattacharya, Jahar

AU - Koval, Michael

PY - 2004/9

Y1 - 2004/9

N2 - Tight junction barrier formation and gap junctional communication are two functions directly attributable to cell-cell contact sites. Epithelial and endothelial tight junctions are critical elements of the permeability barrier required to maintain discrete compartments in the lung. On the other hand, gap junctions enable a tissue to act as a cohesive unit by permitting metabolic coupling and enabling the direct transmission of small cytosolic signaling molecules from one cell to another. These components do not act in isolation since other junctional elements, such as adherens junctions, help regulate barrier function and gap junctional communication. Some fundamental elements related to regulation of pulmonary barrier function and gap junctional communication were presented in a Featured Topic session at the 2004 Experimental Biology Conference in Washington, DC, and are reviewed in this summary.

AB - Tight junction barrier formation and gap junctional communication are two functions directly attributable to cell-cell contact sites. Epithelial and endothelial tight junctions are critical elements of the permeability barrier required to maintain discrete compartments in the lung. On the other hand, gap junctions enable a tissue to act as a cohesive unit by permitting metabolic coupling and enabling the direct transmission of small cytosolic signaling molecules from one cell to another. These components do not act in isolation since other junctional elements, such as adherens junctions, help regulate barrier function and gap junctional communication. Some fundamental elements related to regulation of pulmonary barrier function and gap junctional communication were presented in a Featured Topic session at the 2004 Experimental Biology Conference in Washington, DC, and are reviewed in this summary.

KW - Cadherin

KW - Calcium

KW - Claudin

KW - Connexin

KW - Gap junction

KW - Tight junction

UR - http://www.scopus.com/inward/record.url?scp=4143101264&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=4143101264&partnerID=8YFLogxK

U2 - 10.1152/ajplung.00172.2004

DO - 10.1152/ajplung.00172.2004

M3 - Article

C2 - 15308493

AN - SCOPUS:4143101264

VL - 287

JO - American Journal of Physiology

JF - American Journal of Physiology

SN - 0363-6143

IS - 3 31-3

ER -