Cell cycle checkpoints, genetic instability and cancer

Ted Weinert, David Lydall

Research output: Contribution to journalArticle

126 Scopus citations

Abstract

During the cell cycle, the order of events is maintained by controls termed checkpoints. Two checkpoints are sensitive to DNA damage, one that acts before mitosis and a second that acts before DNA replication. This is relevant to cancer because checkpoint mutants show genetic instability, and such instability is characteristic of many cancers. Studies of checkpoints in normal and cancer cells suggest a mechanistic relationship to the central cell cycle control p34CDC2 and its regulators. We suggest how mutations in these genes and those with a role in DNA metabolism may affect the function of checkpoints. A further link between checkpoints and cancer may be the p53 protein, which appears to Junction at the G1-S checkpoint. Consideration of checkpoints may provide more effective means for cancer treatment.

Original languageEnglish (US)
Pages (from-to)129-140
Number of pages12
JournalSeminars in Cancer Biology
Volume4
Issue number2
Publication statusPublished - 1993

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Keywords

  • Cell cycle
  • Checkpoints
  • DNA repair
  • p53
  • RAD9

ASJC Scopus subject areas

  • Cancer Research

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