Cell-free dna as an addition to ultrasound for screening of a complete hydatidiform mole and coexisting normal fetus pregnancy: A case report

Martina G. Gabra, Maritza G. Gonzalez, Holly N. Bullock, Meghan G. Hill

Research output: Contribution to journalArticle

Abstract

Background  Complete hydatidiform mole and coexisting normal fetus pregnancies (CHMCF) are rare and can be life-threatening to the mother. Definitive diagnosis can be made with chorionic villus sampling or amniocentesis. However invasive procedures carry a risk of bleeding. We present the case of a twin molar pregnancy where a cell-free DNA screening test was utilized to evaluate for CHMCF pregnancy. Case A patient presented at 15-week gestational age with suspected CHMCF pregnancy. Ultrasound revealed a normal-appearing pregnancy abutting a multicystic lesion concerning for a complete mole. Cell-free DNA was obtained and was suggestive of complete paternal uniparental disomy. Pathological evaluation of the products of conception confirmed the diagnosis of CHMCF. Conclusion In atypical cases, cell-free DNA may be useful in evaluation of molar pregnancy

Original languageEnglish (US)
Pages (from-to)E176-E178
JournalAJP Reports
Volume10
Issue number2
DOIs
StatePublished - Apr 1 2020

Keywords

  • Cell-free dna
  • Complete hydatidiform mole and coexisting normal fetus
  • Hyperemesis gravidarum
  • Twin-molar pregnancy

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

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