Cell surface engineering and application in cell delivery to heart diseases 09 Engineering 0903 Biomedical Engineering

Daniel Y. Lee, Byung Hyun Cha, Minjin Jung, Angela S. Kim, David A. Bull, Young Wook Won

Research output: Contribution to journalReview articlepeer-review

22 Scopus citations

Abstract

Cell-based therapy has expanded its influence in cancer immunotherapy, regenerative medicine, and tissue engineering. Due to their secretory functions, differentiation capabilities, specific homing effects through chemotaxis, distinctive therapeutic potentials, and ex vivo expandability, cells have become an attractive reagent for advanced therapeutic strategies. Therefore, the ability to modify cells and manipulate their functions according to intended therapeutic designs has been the central scientific interest in the field of biomedical research. Many innovative methods have been developed with genetic modification of cells being the most advanced cell surface engineering technique. Although genetic modification is a powerful tool, it has a limited applicability due to the permanent modifications made on cells. Alternatively, many endeavors have been made to develop surface engineering techniques that can circumvent the limitations of genetic modification. In this review, current methods of non-genetic cell surface modification, including chemical conjugations, polymeric encapsulation, hydrophobic insertion, enzymatic and metabolic addition, will be introduced. Moreover, cell surface engineering plausible for cardiac remodeling and the future prospective will be discussed at the end.

Original languageEnglish (US)
Article number28
JournalJournal of Biological Engineering
Volume12
Issue number1
DOIs
StatePublished - Dec 4 2018

Keywords

  • Cell surface engineering
  • cardiac diseases
  • cardiac repair
  • cell modification
  • cell therapy
  • mesenchymal stem cells

ASJC Scopus subject areas

  • Environmental Engineering
  • Biomedical Engineering
  • Molecular Biology
  • Cell Biology

Fingerprint

Dive into the research topics of 'Cell surface engineering and application in cell delivery to heart diseases 09 Engineering 0903 Biomedical Engineering'. Together they form a unique fingerprint.

Cite this