Cellular eukaryotic initiation factor 5A content as a mediator of polyamine effects on growth and apoptosis

Margaret E. Tome, Eugene W. Gerner

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

The polyamines are essential for eukaryotic cell growth. One of the most critical effects of polyamines on cell growth is the availability of spermidine for the post-translational modification of eIF-5A. Because hypusine-containing eIF-5A is necessary for cell proliferation, depletion of cellular polyamines suppresses growth by depleting cellular modified eIF-5A content. Excess putrescine accumulations in DH23A/b cells induces apoptosis and suppresses the formation of hypusme-containing eIF-5A. Treatment of DH23A/b cells with diaminoheptane also suppresses modified eIF-5A formation and induces apoptosis. These data suggest that suppression of modified eIF-5A formation may play a role in putrescine-induced apoptosis as well.

Original languageEnglish (US)
Pages (from-to)150-156
Number of pages7
JournalNeuroSignals
Volume6
Issue number3
DOIs
StatePublished - Jan 1 1997

Keywords

  • Apoptosis
  • Cell growth
  • Polyamines
  • Putrescine
  • eIF-5A

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience
  • Cellular and Molecular Neuroscience

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