Abstract
The effects of long-term consumption of 13-cis retinoic acid (13-cRA) on cellular immune functions were measured in young, adult volunteers. The retinoid was administered for 9 months at about 0.13 mg/kg/day. The mean 8AM concentrations of 13-cRA ranged between 30 and 60 ng/ml of serum throughout the study. Corticosteroid levels in plasma decreased significantly throughout treatment, declining from 15.2 ug/dL to 9.1 mg/dL (p < 0.05). T-cell mitogenesis stimulated by PHA or A Con A was not significantly affected, although this parameter was slightly depressed during the first 2 months of treatment. The percentage of B-lymphocytes tended to decrease during treatment and returned to normal after cessation of 13-cRA (p < 0.05), while the percentage of T-cells as measured by E-rosette and by fluorescent antibody tagging of surface antigens did not change. The percentage of non T-cells tended to increase slightly during treatment.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 567-577 |
| Number of pages | 11 |
| Journal | Journal of Leukocyte Biology |
| Volume | 39 |
| Issue number | 5 |
| State | Published - 1986 |
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ASJC Scopus subject areas
- Cell Biology
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Cellular immune functions of adults treated with a daily, long-term, low dose of 13-cis retinoic acid. / Watson, Ronald R; Jackson, J. C.; Alberts, David S; Hicks, M. J.
In: Journal of Leukocyte Biology, Vol. 39, No. 5, 1986, p. 567-577.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cellular immune functions of adults treated with a daily, long-term, low dose of 13-cis retinoic acid
AU - Watson, Ronald R
AU - Jackson, J. C.
AU - Alberts, David S
AU - Hicks, M. J.
PY - 1986
Y1 - 1986
N2 - The effects of long-term consumption of 13-cis retinoic acid (13-cRA) on cellular immune functions were measured in young, adult volunteers. The retinoid was administered for 9 months at about 0.13 mg/kg/day. The mean 8AM concentrations of 13-cRA ranged between 30 and 60 ng/ml of serum throughout the study. Corticosteroid levels in plasma decreased significantly throughout treatment, declining from 15.2 ug/dL to 9.1 mg/dL (p < 0.05). T-cell mitogenesis stimulated by PHA or A Con A was not significantly affected, although this parameter was slightly depressed during the first 2 months of treatment. The percentage of B-lymphocytes tended to decrease during treatment and returned to normal after cessation of 13-cRA (p < 0.05), while the percentage of T-cells as measured by E-rosette and by fluorescent antibody tagging of surface antigens did not change. The percentage of non T-cells tended to increase slightly during treatment.
AB - The effects of long-term consumption of 13-cis retinoic acid (13-cRA) on cellular immune functions were measured in young, adult volunteers. The retinoid was administered for 9 months at about 0.13 mg/kg/day. The mean 8AM concentrations of 13-cRA ranged between 30 and 60 ng/ml of serum throughout the study. Corticosteroid levels in plasma decreased significantly throughout treatment, declining from 15.2 ug/dL to 9.1 mg/dL (p < 0.05). T-cell mitogenesis stimulated by PHA or A Con A was not significantly affected, although this parameter was slightly depressed during the first 2 months of treatment. The percentage of B-lymphocytes tended to decrease during treatment and returned to normal after cessation of 13-cRA (p < 0.05), while the percentage of T-cells as measured by E-rosette and by fluorescent antibody tagging of surface antigens did not change. The percentage of non T-cells tended to increase slightly during treatment.
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UR - http://www.scopus.com/inward/citedby.url?scp=0022586279&partnerID=8YFLogxK
M3 - Article
C2 - 2939161
AN - SCOPUS:0022586279
VL - 39
SP - 567
EP - 577
JO - Journal of Leukocyte Biology
JF - Journal of Leukocyte Biology
SN - 0741-5400
IS - 5
ER -