Cellular immune modulation after a single high dose of levamisole in patients with carcinoma

Uri H. Lewinski, Giora M. Mavligit, Evan M. Hersh

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

The effect of a single high dose of Levamisole (200 mg/M2) on delayed‐type hypersensitivity (DTH) in vivo and on lymphocyte blastogenesis to mitogens and antigens in vitro was studied in 26 patients with carcinoma. Similar studies were conducted in 24 control patients. Levamisole had a moderate but significant enhancing effect on DTH to Dermatophytin detectable no earlier than eight hours and still present at 48 hours after the drug administration. A moderate but significant enhancing effect on lymphocyte blastogenesis to mitogens and antigens was also demonstrated during the same time sequence. Further clinical trials with Levamisole should be conducted with more attention paid to schedule of drug administration.

Original languageEnglish (US)
Pages (from-to)2185-2194
Number of pages10
JournalCancer
Volume46
Issue number10
DOIs
StatePublished - Nov 15 1980

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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