Cellular immunity in man: Correlation of leukocyte migration inhibition factor formation and delayed hypersensitivity

John E. Curtis, Evan M. Hersh

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

The formation of leukocyte migration inhibition factor (MIF) by the lymphocytes of 13 normal persons immune to the protein antigen keyhole limpet hemocyanin (KLH) has been investigated. KLH-induced MIF formation expressed as percent migration was compared with delayed hypersensitivity, antibody, and in vitro lymphocyte blastogenic responses to this antigen. Individuals were studied 404-840 days (median 540 days) after their last exposure to KLH. Nine persons had delayed hypersensitivity to KLH and 10 had circulating KLH antibody. The lymphocytes of 11 showed an in vitro blastogenic response to KLH stimulation, while the lymphocytes of nine produced MIF after KLH stimulation. The mean percent migration for the subjects with KLH delayed hypersensitivity was 48.2 (range 20.4-70.4) compared with 133 (range 120-161) for the four persons who did not have KLH delayed hypersensitivity (P < 0.05). The correlation coefficient between the precent migration and delayed hypersensitivity was -0.78 (P < 0.01). No correlation was demonstrated between migration inhibition and the other parameters of immunity.

Original languageEnglish (US)
Pages (from-to)55-61
Number of pages7
JournalCellular Immunology
Volume8
Issue number1
DOIs
StatePublished - Jul 1973

ASJC Scopus subject areas

  • Immunology

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