Cellular networks underlying human spatial navigation

Arne D. Ekstrom, Michael J. Kahana, Jeremy B. Caplan, Tony A. Fields, Eve A. Isham, Ehren L. Newman, Itzhak Fried

Research output: Contribution to journalArticle

755 Citations (Scopus)

Abstract

Place cells of the rodent hippocampus constitute one of the most striking examples of a correlation between neuronal activity and complex behaviour in mammals. These cells increase their firing rates when the animal traverses specific regions of its surroundings, providing a context-dependent map of the environment. Neuroimaging studies implicate the hippocampus and the parahippocampal region in human navigation. However, these regions also respond selectively to visual stimuli. It thus remains unclear whether rodent place coding has a homologue in humans or whether human navigation is driven by a different, visually based neural mechanism. We directly recorded from 317 neurons in the human medial temporal and frontal lobes while subjects explored and navigated a virtual town. Here we present evidence for a neural code of human spatial navigation based on cells that respond at specific spatial locations and cells that respond to views of landmarks. The former are present primarily in the hippocampus, and the latter in the parahippocampal region. Cells throughout the frontal and temporal lobes responded to the subjects' navigational goals and to conjunctions of place, goal and view.

Original languageEnglish (US)
Pages (from-to)184-187
Number of pages4
JournalNature
Volume425
Issue number6954
DOIs
StatePublished - Sep 11 2003
Externally publishedYes

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Hippocampus
Frontal Lobe
Temporal Lobe
Rodentia
Neuroimaging
Mammals
Spatial Navigation
Neurons
Place Cells

ASJC Scopus subject areas

  • General

Cite this

Ekstrom, A. D., Kahana, M. J., Caplan, J. B., Fields, T. A., Isham, E. A., Newman, E. L., & Fried, I. (2003). Cellular networks underlying human spatial navigation. Nature, 425(6954), 184-187. https://doi.org/10.1038/nature01964

Cellular networks underlying human spatial navigation. / Ekstrom, Arne D.; Kahana, Michael J.; Caplan, Jeremy B.; Fields, Tony A.; Isham, Eve A.; Newman, Ehren L.; Fried, Itzhak.

In: Nature, Vol. 425, No. 6954, 11.09.2003, p. 184-187.

Research output: Contribution to journalArticle

Ekstrom, AD, Kahana, MJ, Caplan, JB, Fields, TA, Isham, EA, Newman, EL & Fried, I 2003, 'Cellular networks underlying human spatial navigation', Nature, vol. 425, no. 6954, pp. 184-187. https://doi.org/10.1038/nature01964
Ekstrom AD, Kahana MJ, Caplan JB, Fields TA, Isham EA, Newman EL et al. Cellular networks underlying human spatial navigation. Nature. 2003 Sep 11;425(6954):184-187. https://doi.org/10.1038/nature01964
Ekstrom, Arne D. ; Kahana, Michael J. ; Caplan, Jeremy B. ; Fields, Tony A. ; Isham, Eve A. ; Newman, Ehren L. ; Fried, Itzhak. / Cellular networks underlying human spatial navigation. In: Nature. 2003 ; Vol. 425, No. 6954. pp. 184-187.
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