Central modulation of pain

Michael H. Ossipov, Gregory O. Dussor, Frank Porreca

Research output: Contribution to journalReview article

489 Scopus citations


It has long been appreciated that the experience of pain is highly variable between individuals. Pain results from activation of sensory receptors specialized to detect actual or impending tissue damage (i.e., nociceptors). However, a direct correlation between activation of nociceptors and the sensory experience of pain is not always apparent. Even in cases in which the severity of injury appears similar, individual pain experiences may vary dramatically. Emotional state, degree of anxiety, attention and distraction, past experiences, memories, and many other factors can either enhance or diminish the pain experience. Here, we review evidence for "top-down" modulatory circuits that profoundly change the sensory experience of pain.

Original languageEnglish (US)
Pages (from-to)3779-3787
Number of pages9
JournalJournal of Clinical Investigation
Issue number11
StatePublished - Nov 1 2010


ASJC Scopus subject areas

  • Medicine(all)

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