Central nervous system genomics.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

In the past 25 years, remarkable progress has been made in our understanding of genomics and its influence on central nervous system diseases. In this chapter, common diseases of the central nervous system will be reviewed along with the genomics associated with these diseases. The diseases/injuries that will be investigated include neurovascular disorders such as ischemic stroke, hemorrhagic stroke, subarachnoid hemorrhage, and traumatic brain injury. This chapter will also explore Apolipoprotein E (APOE), a 299-aminoacid protein encoded by the APOE gene, and its associations with many of the previously named diseases. APOE was first tied to the risk of Alzheimer's disease and has since then been investigated in traumatic brain injury and hemorrhagic strokes. In addition, we will discuss the future of genomic research in central nervous system diseases.

Original languageEnglish (US)
Pages (from-to)205-226
Number of pages22
JournalAnnual review of nursing research
Volume29
DOIs
StatePublished - 2011

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Central Nervous System Diseases
Apolipoproteins E
Genomics
Central Nervous System
Stroke
Subarachnoid Hemorrhage
Alzheimer Disease
Wounds and Injuries
Research
Genes
Proteins
Traumatic Brain Injury

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Central nervous system genomics. / Gallek, Matthew J; Ritter, Leslie.

In: Annual review of nursing research, Vol. 29, 2011, p. 205-226.

Research output: Contribution to journalArticle

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