Central neurons are depressed by iontophoretic and micropressure application of ethanol and tetrahydropapaveroline

George R. Siggins, Edward French

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

In an attempt to circumvent the complexities of systemically administered ethanol and tetrahydroisoquinolines (TIQs), iontophoresis and micropressure application were used to test these agents in single rat neurons. Alcohol applied by either method depressed cerebellar Purkinje cells in a concentration-dependent, non-specific, local anesthetic-like manner. Tests of tetrahydropapaveroline · HCl (THP) on neurons from three brain areas also showed depression of spontaneous discharge, although, in contrast to ethanol, little or no local anesthetic-like action was observed, and at equivalent ejection currents or pressures, the THP depressions appeared to be more pronounced. The underlying mechanisms for these responses are unknown.

Original languageEnglish (US)
Pages (from-to)239-243
Number of pages5
JournalDrug and Alcohol Dependence
Volume4
Issue number3-4
DOIs
StatePublished - Jan 1 1979

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology
  • Psychiatry and Mental health
  • Pharmacology (medical)

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