Cerebral infarction associated with lupus anticoagulants. Preliminary report

R. G. Hart, V. T. Miller, Bruce M Coull, V. Bril

Research output: Contribution to journalArticle

117 Citations (Scopus)

Abstract

Hypercoagulability may contribute to stroke in young adults. Lupus anticoagulants (LA) were identified in six patients (4%) of 145 young adults with cerebral infarction. The clinical features of the 6 patients in this survey plus an additional patient from another institution with LA-associated stroke are presented. Four had systemic lupus erythematosus and 3 had idiopathic LA; all had mild thrombocytopenia. In 2 patients, no other conditions associated with stroke were discovered after thorough evaluation. Recurrent arterial thrombosis occurred in 4 of 7 patients during an average of two years of follow-up. Evidence suggests that inhibition of prostacyclin formation may occur with LA, promoting a prothrombotic state.

Original languageEnglish (US)
Pages (from-to)114-118
Number of pages5
JournalStroke
Volume15
Issue number1
StatePublished - 1984
Externally publishedYes

Fingerprint

Lupus Coagulation Inhibitor
Cerebral Infarction
Stroke
Young Adult
Thrombophilia
Epoprostenol
Thrombocytopenia
Systemic Lupus Erythematosus
Thrombosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Neuroscience(all)

Cite this

Hart, R. G., Miller, V. T., Coull, B. M., & Bril, V. (1984). Cerebral infarction associated with lupus anticoagulants. Preliminary report. Stroke, 15(1), 114-118.

Cerebral infarction associated with lupus anticoagulants. Preliminary report. / Hart, R. G.; Miller, V. T.; Coull, Bruce M; Bril, V.

In: Stroke, Vol. 15, No. 1, 1984, p. 114-118.

Research output: Contribution to journalArticle

Hart, RG, Miller, VT, Coull, BM & Bril, V 1984, 'Cerebral infarction associated with lupus anticoagulants. Preliminary report', Stroke, vol. 15, no. 1, pp. 114-118.
Hart, R. G. ; Miller, V. T. ; Coull, Bruce M ; Bril, V. / Cerebral infarction associated with lupus anticoagulants. Preliminary report. In: Stroke. 1984 ; Vol. 15, No. 1. pp. 114-118.
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