Cerebrospinal fluid penetration of cefpirome in patients with noninflamed meninges

David E. Nix, John H. Wilton, Norma Velasquez, James L. Budny, Howard B. Lassman, Patricia Mitchell, Kishore Divan, Jerome J. Schentag

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12 Scopus citations

Abstract

Twenty patients (mean age 52±12 years, mean weight 75± 15 kg) scheduled for elective myelogram or spinal anaesthesia were enrolled to determine the cerebrospinal fluid (CSF) penetration of a new expanded spectrum cephalosporin antibiotic, cefpirome (HR-810). A single 2 g intravenous dose of cefpirome was administered as a bolus between 1 and 8 h before lumbar puncture. Blood samples were collected at 15 pre-determined times and a single CSF sample was obtained at the time of lumbar puncture. Serum and CSF cefpirome concentrations were determined by high performance liquid chromatography. The mean maximal serum concentration of cefpirome was 264±76 mg/L. A mean steady-state volume of distribution of 20±4 L, clearance of 7·4±l·3 L/h, and half-life of 2·5±0·5 h were determined. Mean CSF concentrations were 0·50 ±0·11 mg/L at 1-2 h post dose (n = 4), 0·57±0·13 mg/L at 2-4 h post dose (n = 4), 0·76±0·34 mg/L at 4-6 h post dose (n = 7), and 0·83±0·29 mg/L at 6-8·3 h post dose (n = 5). Blood: brain barrier permeability to cefpirome may not be a limiting factor as CSF concentrations were rapidly attained. Further studies are required to determine the mechanism of cefpirome transport between plasma and CSF.

Original languageEnglish (US)
Pages (from-to)51-57
Number of pages7
JournalJournal of Antimicrobial Chemotherapy
Volume29
DOIs
StatePublished - 1992
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Microbiology (medical)
  • Infectious Diseases
  • Pharmacology (medical)

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