Changes in esophageal wall layers during motility: measurements with a new miniature ultrasound suction device

Darik K. Taniguchi, Roy W. Martin, Eugene A. Trowers, Meivin B. Dennis, Svein ∅degaard, Fred E. Silverstein

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

We have developed a miniaturized ultrasound device that attaches to the gastrointestinal mucosa by suction and produces high-resolution (±0.1 mm) images of the layers of the intestinal wall. The esophageal wall layers in a single sheep were measured during 20 occlusive contractions observed with simultaneous endoscopy, which revealed thickening of the inner circular muscle layer from 1.2 ± 0.2 mm to 2.2 ± 0.4 mm (p < 0.01), and during 20 dilations demonstrating thinning of the full thickness of the esophageal wall from 3.6 ± 0.3 mm to 2.9 ± 0.3 mm (p < 0.01). Safety experiments performed in two canine stomachs demonstrated no erosions or ulceration at any level of suction. Our investigations indicate that the M-mode suction ultrasound device can safely assess changes occurring in the layers of the esophageal wall during contractions and dilations and should be evaluated for the study of human intestinal motility.

Original languageEnglish (US)
Pages (from-to)146-152
Number of pages7
JournalGastrointestinal endoscopy
Volume39
Issue number2
DOIs
StatePublished - 1993
Externally publishedYes

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Gastroenterology

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