Changes in plasma membrane phospholipids inhibit antibody-mediated lysis

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

A variety of mechanisms have been proposed to explain how tumors evade immune destruction. This work has identified one such mechanism that determines susceptibility to immune lysis; membrane phospholipid composition altered susceptibility to antibody plus complement (Ab. +. C)-mediated lysis. Effects on antibody plus complement-mediated lysis were correlated with levels of major histocompatibility complex (MHC) molecules but not inherent resistance to complement damage. This cellular mechanism could be a means by which tumor cells escape immune detection and destruction.

Original languageEnglish (US)
Pages (from-to)231-236
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume417
Issue number1
DOIs
StatePublished - Jan 6 2012

Keywords

  • Antibody
  • Complement
  • Cytolysis
  • Phospholipids

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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