Changes in plasma membrane phospholipids inhibit antibody-mediated lysis

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

A variety of mechanisms have been proposed to explain how tumors evade immune destruction. This work has identified one such mechanism that determines susceptibility to immune lysis; membrane phospholipid composition altered susceptibility to antibody plus complement (Ab. +. C)-mediated lysis. Effects on antibody plus complement-mediated lysis were correlated with levels of major histocompatibility complex (MHC) molecules but not inherent resistance to complement damage. This cellular mechanism could be a means by which tumor cells escape immune detection and destruction.

Original languageEnglish (US)
Pages (from-to)231-236
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume417
Issue number1
DOIs
StatePublished - Jan 6 2012

Fingerprint

Cell membranes
Tumors
Phospholipids
Cell Membrane
Tumor Escape
Antibodies
Major Histocompatibility Complex
Cells
Membranes
Molecules
Chemical analysis
Neoplasms

Keywords

  • Antibody
  • Complement
  • Cytolysis
  • Phospholipids

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Molecular Biology

Cite this

Changes in plasma membrane phospholipids inhibit antibody-mediated lysis. / Harris, David T.

In: Biochemical and Biophysical Research Communications, Vol. 417, No. 1, 06.01.2012, p. 231-236.

Research output: Contribution to journalArticle

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