Changes of cell shape and surface charge topography in ATP-depleted human red blood cells

Yehuda Marikovsky, Ronald S. Weinstein, Ehud Skutelsky, David Danon

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

ATP depletion crenates human red blood cells. With ferritin-avidin (FA) and cationized ferritin (CF) cell surface labeling, it is demonstrated that the discocyte → crenated shape transformation alters the two-dimensional topography of negative charge sites. With restoration of ATP levels, cell shape and charge topography return to normal. Concurrent changes in red cell shape and surface charge topography can be explained by associations between membrane integral proteins and the red cell cytoskeleton.

Original languageEnglish (US)
Pages (from-to)309-316
Number of pages8
JournalMechanisms of Ageing and Development
Volume29
Issue number3
DOIs
StatePublished - Mar 1985
Externally publishedYes

Keywords

  • ATP-depletion
  • Cell shape
  • Erythrocyte
  • Surface charge

ASJC Scopus subject areas

  • Aging
  • Developmental Biology

Fingerprint Dive into the research topics of 'Changes of cell shape and surface charge topography in ATP-depleted human red blood cells'. Together they form a unique fingerprint.

Cite this