Chapter 11 Unexpected Turns and Twists in Structure/Function of PR-Proteins that Connect Energy Metabolism and Immunity

Meena L. Narasimhan, Ray A. Bressan, Matilde Paino D'Urzo, Matthew A. Jenks, Tesfaye Mengiste

Research output: Contribution to journalReview article

10 Citations (Scopus)

Abstract

Innate immunity in plants is manifested by a complex array of antimicrobial processes that includes induction of sets of pathogenesis-related (PR) proteins. The availability of genomic data has made clear that each PR-protein family in a species is represented by several genes. Microarray data in public databases show that in most families, including the PR-5 family surveyed here, the expression of only few family members is defense associated. Genetic studies show that depending on their nutrient acquisition strategy, pathogens induce distinct but overlapping sets of PR genes, suggesting a connection to energy or resource allocation. PR-5 proteins have a clearly recognizable structure that is referred to as the thaumatin (THN) domain, which can be overlapped with mammalian Complement 1q-tumor necrosis factor (C1q-TNF) domains such as that of the mammalian hormone adiponectin. The occurrence of THN domain proteins is widespread. Similarities between THN domain proteins and mammalian C1q-TNF family proteins include their ligands and their subcellular locations. Osmotin (tobacco PR-5c) regulates energy balance signaling in mammalian cells by interaction with adiponectin receptors by a pathway that shares components with plant energy and stress signaling pathways. These data suggest additional roles for PR-5 proteins, as scaffolds and/or in signaling, particularly in regulating energy balance.

Original languageEnglish (US)
Pages (from-to)439-489
Number of pages51
JournalAdvances in Botanical Research
Volume51
Issue numberC
DOIs
StatePublished - Dec 1 2009
Externally publishedYes

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pathogenesis-related proteins
protein metabolism
energy metabolism
pathogenesis
immunity
tumor necrosis factors
proteins
energy balance
complement
adiponectin
energy
resource allocation
tobacco
genes
anti-infective agents
hormones
genomics
pathogens
nutrients
cells

ASJC Scopus subject areas

  • Plant Science

Cite this

Chapter 11 Unexpected Turns and Twists in Structure/Function of PR-Proteins that Connect Energy Metabolism and Immunity. / Narasimhan, Meena L.; Bressan, Ray A.; D'Urzo, Matilde Paino; Jenks, Matthew A.; Mengiste, Tesfaye.

In: Advances in Botanical Research, Vol. 51, No. C, 01.12.2009, p. 439-489.

Research output: Contribution to journalReview article

Narasimhan, Meena L. ; Bressan, Ray A. ; D'Urzo, Matilde Paino ; Jenks, Matthew A. ; Mengiste, Tesfaye. / Chapter 11 Unexpected Turns and Twists in Structure/Function of PR-Proteins that Connect Energy Metabolism and Immunity. In: Advances in Botanical Research. 2009 ; Vol. 51, No. C. pp. 439-489.
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