Chapter 16 Glucagon: Molecular biology and structure-activity

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Abstract

The actions of glucagon at hepatic and fat cell receptors is critical for the control of glucose levels and glucose homeostasis in normal and diabetic states. Its interactions with insulin in maintaining homeostasis in normal animals is understood in considerable detail and tools are now available to obtain an even deeper understanding. In the diabetic state, the interplay of glucagon and insulin (and other factors) in hyperglycemia, ketoses, and other manifestations of diabetes is less clear, and provides a continuing challenge for biochemists, physiologists, endocrinologists, and molecular biologists. Fortunately, new tools in the form of potent receptor agonists and antagonists, cloned receptors, assays with enhanced sensitivity, and increased understanding of receptor transduction mechanism should greatly aid in obtaining these needed new insights and understanding.

Original languageEnglish (US)
Title of host publicationPrinciples of Medical Biology
PublisherElsevier Inc.
Pages387-401
Number of pages15
EditionC
DOIs
StatePublished - 1998

Publication series

NamePrinciples of Medical Biology
NumberC
Volume10
ISSN (Print)1569-2582

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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