Characteristics relating to ovarian cancer risk: Collaborative analysis of seven U.S. Case-control studies. epithelial ovarian cancer in black women

Esther M. John, Alice S. Whittemore, Robin B Harris, Jacqueline Itnyre

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

Background: Previous epidemiologic studies of ovarian cancer have focused chiefly on White women, who have a higher incidence of ovarian cancer than Black women. No study has previously examined risk factors for ovarian cancer among Black women. Purpose: This study was designed to evaluate the risk of epithelial ovarian cancer in Black women in relation to reproductive characteristics such as pregnancy, oral contraceptive use, and breast-feeding, and to determine whether differences in reproductive factors between Black and White women account for differences in ovarian cancer incidence. Methods: Combining interview data from seven case-control studies, we compared reproductive characteristics of 110 Black case subjects with a diagnosis of epithelial ovarian cancer between 1971 and 1986 with characteristics of 251 Black population control subjects and 114 Black hospital control subjects. We also compared the prevalence of reproductive factors in 246 Black population control subjects and 4378 White population control subjects and estimated the fraction of Black-White differences in ovarian cancer incidence attributable to racial differences in prevalence of these characteristics. Results: Decreased risks of epithelial ovarian cancer in Black women were associated with parity of four or higher (odds ratio [OR]=0.53; 95% confidence interval [CI]=0.25-1.1), breast-feeding for 6 months or longer (OR=0.85; 95% CI=0.36-2.0), and use of oral contraceptives for 6 years or longer (OR=0.62; 95% CI=0.24-1.6). A greater proportion of Black women (48%) than White women (27%) reported four or more term pregnancies, and Black women (62%) were more likely than White women (53%) to have breast-fed their children. Oral contraceptive use was more common among White women (59%) than Black women (51%). Conclusions: Differences in the prevalence of other factors related to ovarian cancer risk or differences in genetic susceptibility must explain most of the Black-White differences in incidence of ovarian cancer. [J Natl Cancer Inst 85:142-147, 1993].

Original languageEnglish (US)
Pages (from-to)142-147
Number of pages6
JournalJournal of the National Cancer Institute
Volume85
Issue number2
DOIs
StatePublished - Jan 20 1993
Externally publishedYes

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Ovarian Cancer
Case-control Study
Ovarian Neoplasms
Case-Control Studies
Odds Ratio
Incidence
Population Control
Confidence interval
Oral Contraceptives
Pregnancy
Confidence Intervals
Breast Feeding
Ovarian epithelial cancer
Cancer
Risk Factors
Susceptibility
Parity
Genetic Predisposition to Disease
Proportion
Likely

ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Physiology (medical)
  • Radiology Nuclear Medicine and imaging
  • Oncology
  • Cancer Research

Cite this

Characteristics relating to ovarian cancer risk : Collaborative analysis of seven U.S. Case-control studies. epithelial ovarian cancer in black women. / John, Esther M.; Whittemore, Alice S.; Harris, Robin B; Itnyre, Jacqueline.

In: Journal of the National Cancer Institute, Vol. 85, No. 2, 20.01.1993, p. 142-147.

Research output: Contribution to journalArticle

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abstract = "Background: Previous epidemiologic studies of ovarian cancer have focused chiefly on White women, who have a higher incidence of ovarian cancer than Black women. No study has previously examined risk factors for ovarian cancer among Black women. Purpose: This study was designed to evaluate the risk of epithelial ovarian cancer in Black women in relation to reproductive characteristics such as pregnancy, oral contraceptive use, and breast-feeding, and to determine whether differences in reproductive factors between Black and White women account for differences in ovarian cancer incidence. Methods: Combining interview data from seven case-control studies, we compared reproductive characteristics of 110 Black case subjects with a diagnosis of epithelial ovarian cancer between 1971 and 1986 with characteristics of 251 Black population control subjects and 114 Black hospital control subjects. We also compared the prevalence of reproductive factors in 246 Black population control subjects and 4378 White population control subjects and estimated the fraction of Black-White differences in ovarian cancer incidence attributable to racial differences in prevalence of these characteristics. Results: Decreased risks of epithelial ovarian cancer in Black women were associated with parity of four or higher (odds ratio [OR]=0.53; 95{\%} confidence interval [CI]=0.25-1.1), breast-feeding for 6 months or longer (OR=0.85; 95{\%} CI=0.36-2.0), and use of oral contraceptives for 6 years or longer (OR=0.62; 95{\%} CI=0.24-1.6). A greater proportion of Black women (48{\%}) than White women (27{\%}) reported four or more term pregnancies, and Black women (62{\%}) were more likely than White women (53{\%}) to have breast-fed their children. Oral contraceptive use was more common among White women (59{\%}) than Black women (51{\%}). Conclusions: Differences in the prevalence of other factors related to ovarian cancer risk or differences in genetic susceptibility must explain most of the Black-White differences in incidence of ovarian cancer. [J Natl Cancer Inst 85:142-147, 1993].",
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AB - Background: Previous epidemiologic studies of ovarian cancer have focused chiefly on White women, who have a higher incidence of ovarian cancer than Black women. No study has previously examined risk factors for ovarian cancer among Black women. Purpose: This study was designed to evaluate the risk of epithelial ovarian cancer in Black women in relation to reproductive characteristics such as pregnancy, oral contraceptive use, and breast-feeding, and to determine whether differences in reproductive factors between Black and White women account for differences in ovarian cancer incidence. Methods: Combining interview data from seven case-control studies, we compared reproductive characteristics of 110 Black case subjects with a diagnosis of epithelial ovarian cancer between 1971 and 1986 with characteristics of 251 Black population control subjects and 114 Black hospital control subjects. We also compared the prevalence of reproductive factors in 246 Black population control subjects and 4378 White population control subjects and estimated the fraction of Black-White differences in ovarian cancer incidence attributable to racial differences in prevalence of these characteristics. Results: Decreased risks of epithelial ovarian cancer in Black women were associated with parity of four or higher (odds ratio [OR]=0.53; 95% confidence interval [CI]=0.25-1.1), breast-feeding for 6 months or longer (OR=0.85; 95% CI=0.36-2.0), and use of oral contraceptives for 6 years or longer (OR=0.62; 95% CI=0.24-1.6). A greater proportion of Black women (48%) than White women (27%) reported four or more term pregnancies, and Black women (62%) were more likely than White women (53%) to have breast-fed their children. Oral contraceptive use was more common among White women (59%) than Black women (51%). Conclusions: Differences in the prevalence of other factors related to ovarian cancer risk or differences in genetic susceptibility must explain most of the Black-White differences in incidence of ovarian cancer. [J Natl Cancer Inst 85:142-147, 1993].

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