Characterization of High-Salt and High-Fat Diets on Cardiac and Vascular Function in Mice

Qianli Yu, Douglas F Larson, Denise Slayback, Tamara F. Lundeen, Jeffrey H. Baxter, Ronald R Watson

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

This study compared two established dietary formulations, high salt and high fat-high carbohydrate, separately or in combination on the induction cardiovascular dysfunction. One-month-old C57BL/6J mice were fed one of the following diets for 3 mo: (1) control diet consisting of a high fat-high simple carbohydrate (HFHSC); (2) 8% NaCl diet (HS); or (3) HFHSC diet supplemented with 1% NaCl (HFHS). After 3 mo, the HFHSC mice demonstrated significantly increased end-diastolic volume and end-systolic volume, specifically increases of 35% and 78%, respectively (p < 0.01) and a reduction of ventricular stiffness by 27% (p = 0.015). The HS mice exhibited arterial hypertension with an increase of 33% in maximum end-systolic pressure (p = .024) and a decrease of 44% in arterial elastance (p = 0.020), corroborated by an increase in the heart weight to body weight ratios (p = 0.002) and vascular types I and III collagen (p = 0.03 and p = 0.0008, respectively). The HFHS group revealed a striking response of 230% to the α1-adrenergic challenge (p = 0.00034). These data suggest that the HFHSC diet causes dilated cardiomyopathy, whereas the HS diet produces arterial hypertension and the HFHS diet causes a vascular dysfunctional state that was highly responsive to α-adrenergic stimulation.

Original languageEnglish (US)
Pages (from-to)37-46
Number of pages10
JournalCardiovascular Toxicology
Volume4
Issue number1
DOIs
StatePublished - 2004

Fingerprint

High Fat Diet
Nutrition
Blood Vessels
Salts
Fats
Diet
Carbohydrates
Adrenergic Agents
Hypertension
Formulated Food
Collagen Type III
Dilated Cardiomyopathy
Collagen Type I
Inbred C57BL Mouse
Body Weight
Stiffness
Blood Pressure
Weights and Measures

Keywords

  • C57BL/6
  • Cardiomyopathy
  • Conductance catheter
  • Heart function
  • Hypertension
  • Sodium chloride intake
  • Vascular function

ASJC Scopus subject areas

  • Toxicology
  • Cardiology and Cardiovascular Medicine

Cite this

Characterization of High-Salt and High-Fat Diets on Cardiac and Vascular Function in Mice. / Yu, Qianli; Larson, Douglas F; Slayback, Denise; Lundeen, Tamara F.; Baxter, Jeffrey H.; Watson, Ronald R.

In: Cardiovascular Toxicology, Vol. 4, No. 1, 2004, p. 37-46.

Research output: Contribution to journalArticle

Yu, Qianli ; Larson, Douglas F ; Slayback, Denise ; Lundeen, Tamara F. ; Baxter, Jeffrey H. ; Watson, Ronald R. / Characterization of High-Salt and High-Fat Diets on Cardiac and Vascular Function in Mice. In: Cardiovascular Toxicology. 2004 ; Vol. 4, No. 1. pp. 37-46.
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