Characterization of poly(3,4-ethylenedioxythiophene): Tosylate conductive polymer microelectrodes for transmitter detection

Simon T. Larsen, Richard F. Vreeland, Michael L Heien, Rafael Taboryski

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

In this paper we investigate the physical and electrochemical properties of micropatterned poly(3,4-ethylenedioxythiophene):tosylate (PEDOT:tosylate) microelectrodes for neurochemical detection. PEDOT:tosylate is a promising conductive polymer electrode material for chip-based bioanalytical applications such as capillary electrophoresis, high-performance liquid chromatography, and constant potential amperometry at living cells. Band electrodes with widths down to 3 μm were fabricated on polymer substrates using UV lithographic methods. The electrodes are electrochemically stable in a range between -200 mV and 700 mV vs. Ag/AgCl and show a relatively low resistance. A wide range of transmitters is shown to oxidize readily on the electrodes. Kinetic rate constants and half wave potentials are reported. The capacitance per area was found to be high (1670 ± 130 μF cm -2) compared to other thin film microelectrode materials. Finally, we use constant potential amperometry to measure the release of transmitters from a group of PC 12 cells. The results show how the current response decreases for a series of stimulations with high K + buffer.

Original languageEnglish (US)
Pages (from-to)1831-1836
Number of pages6
JournalAnalyst
Volume137
Issue number8
DOIs
StatePublished - Apr 21 2012

Fingerprint

Microelectrodes
Transmitters
Polymers
Electrodes
electrode
polymer
Capillary electrophoresis
Capillary Electrophoresis
High performance liquid chromatography
Electrochemical properties
liquid chromatography
Rate constants
electrokinesis
Buffers
Capacitance
Physical properties
High Pressure Liquid Chromatography
Cells
substrate
Thin films

ASJC Scopus subject areas

  • Analytical Chemistry
  • Spectroscopy
  • Electrochemistry
  • Biochemistry
  • Environmental Chemistry

Cite this

Characterization of poly(3,4-ethylenedioxythiophene) : Tosylate conductive polymer microelectrodes for transmitter detection. / Larsen, Simon T.; Vreeland, Richard F.; Heien, Michael L; Taboryski, Rafael.

In: Analyst, Vol. 137, No. 8, 21.04.2012, p. 1831-1836.

Research output: Contribution to journalArticle

Larsen, Simon T. ; Vreeland, Richard F. ; Heien, Michael L ; Taboryski, Rafael. / Characterization of poly(3,4-ethylenedioxythiophene) : Tosylate conductive polymer microelectrodes for transmitter detection. In: Analyst. 2012 ; Vol. 137, No. 8. pp. 1831-1836.
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