Characterization of renal brush-border and basolateral membrane transporters for organic cations

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

The renal proximal tubule is the site of active secretion of a diverse array of organic cations and bases (collectively, OCs). The basolateral entry step in transtubule OC transport involves an electrogenic facilitated diffusion process. OC exit into the tubule lumen is the active step in secretion and involves the carrier-mediated exchange of OC for H+. The specificity of these two processes is influenced less by steric characteristics of substrates than by their chemical lipophilicity, with both transporters displaying an increasing affinity for OCs of increasing lipophilicity. Several additional OC transporters exist within each membrane and the concerted activity of these processes permits the proximal tubule to effect the secretion of most OCs, and the selective reabsorption of others, and provides the tubule with a degree of “redundancy” in the means available for secreting potentially toxic xenobiotic compounds from the body.

Original languageEnglish (US)
Pages (from-to)112-122
Number of pages11
JournalCellular Physiology and Biochemistry
Volume6
Issue number1-2
DOIs
StatePublished - Sep 4 1996

Keywords

  • Basolateral membrane
  • Brush-border membrane
  • Kidney
  • Organic cation transport
  • Proximal tubule

ASJC Scopus subject areas

  • Physiology

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