Characterization of responding cells in oxidative mitogen stimulation - III. Presence of I-A- and I-J, E, C-subregion gene products on the surface of required cells

M. Laurie Phillips, Sharon W. Hill, John W. Parker, Richard L. O'Brien, Jeffrey A. Frelinger

Research output: Contribution to journalArticle

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Abstract

Ia antigens coded by genes of the murine major histocompatibility complex are expressed on the surface of a population of cells critical to the proliferative response of murine spleen cells to the oxidative mitogen neuraminidase/galactose oxidase. By selective depletion with antiserum and complement, Ia antigens coded (or determined) by the I-A and I-J, E, C subregions of the Ir region can be detected on the surface of cells required for the response. In addition, I-A-subregion products have a functional significance in cellular activation which can be demonstrated by blocking experiments with anti-la serum in the absence of complement.

Original languageEnglish (US)
Pages (from-to)133-140
Number of pages8
JournalImmunogenetics
Volume10
Issue number1-4
DOIs
StatePublished - Feb 1 1980
Externally publishedYes

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ASJC Scopus subject areas

  • Immunology
  • Genetics

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