Characterization of simian-human immunodeficiency virus envelope glycoprotein epitopes recognized by neutralizing antibodies from infected monkeys

B. Etemad-Moghadam, G. B. Karlsson, M. Halloran, Y. Sun, Dominik Schenten, M. Fernandes, N. L. Letvin, J. Sodroski

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

We characterized human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein epitopes recognized by neutralizing antibodies from monkeys recently infected by molecularly cloned simian-human immunodeficiency virus (SHIV) variants. The early neutralizing antibody response in each infected animal was directed mainly against a single epitope. This primary neutralizing epitope, however, differed among individual monkeys infected by identical viruses. Two such neutralization epitopes were determined by sequences in the V2 and V3 loops of the gp120 envelope glycoprotein, while a third neutralization epitope, apparently discontinuous, was determined by both V2 and V3 sequences. These results indicate that the early neutralizing antibody response in SHIV-infected monkeys is monospecific and directed against epitopes composed of the gp120 V2 and V3 variable loops.

Original languageEnglish (US)
Pages (from-to)8437-8445
Number of pages9
JournalJournal of Virology
Volume72
Issue number10
StatePublished - 1998
Externally publishedYes

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Simian Immunodeficiency Virus
Human immunodeficiency virus
Neutralizing Antibodies
neutralizing antibodies
epitopes
Haplorhini
monkeys
glycoproteins
Epitopes
Glycoproteins
HIV
neutralization
Antibody Formation
Human immunodeficiency virus 1
HIV-1
Viruses
viruses
animals

ASJC Scopus subject areas

  • Immunology

Cite this

Etemad-Moghadam, B., Karlsson, G. B., Halloran, M., Sun, Y., Schenten, D., Fernandes, M., ... Sodroski, J. (1998). Characterization of simian-human immunodeficiency virus envelope glycoprotein epitopes recognized by neutralizing antibodies from infected monkeys. Journal of Virology, 72(10), 8437-8445.

Characterization of simian-human immunodeficiency virus envelope glycoprotein epitopes recognized by neutralizing antibodies from infected monkeys. / Etemad-Moghadam, B.; Karlsson, G. B.; Halloran, M.; Sun, Y.; Schenten, Dominik; Fernandes, M.; Letvin, N. L.; Sodroski, J.

In: Journal of Virology, Vol. 72, No. 10, 1998, p. 8437-8445.

Research output: Contribution to journalArticle

Etemad-Moghadam, B, Karlsson, GB, Halloran, M, Sun, Y, Schenten, D, Fernandes, M, Letvin, NL & Sodroski, J 1998, 'Characterization of simian-human immunodeficiency virus envelope glycoprotein epitopes recognized by neutralizing antibodies from infected monkeys', Journal of Virology, vol. 72, no. 10, pp. 8437-8445.
Etemad-Moghadam, B. ; Karlsson, G. B. ; Halloran, M. ; Sun, Y. ; Schenten, Dominik ; Fernandes, M. ; Letvin, N. L. ; Sodroski, J. / Characterization of simian-human immunodeficiency virus envelope glycoprotein epitopes recognized by neutralizing antibodies from infected monkeys. In: Journal of Virology. 1998 ; Vol. 72, No. 10. pp. 8437-8445.
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