@inproceedings{05228c1c29c445f3aeacac6ea6f743ea,
title = "Characterizing A549 Cell Line as an Epithelial Cell Monolayer Model for Pharmacokinetic Applications",
abstract = "Transport of three different molecules across a porous membrane, with and without a confluent A549 cell monolayer, has been investigated in Transwells and microfluidic devices. The A549 cell line was selected since it has extensively been utilized in toxicology studies due to its potential target for drug delivery of macro molecules. The measured molecular transport rate was found to decrease with increasing molecular size due to lower diffusivity. The confluent cell monolayer presents a barrier to molecular, significantly reducing the transport rate of larger molecules with little effect on the paracellular transport of smaller molecules. The results indicate that the microfluidic system is a good model for pharmacokinetic applications.",
keywords = "A549 cell line, Convection-diffusion flow, Pharmacokinetics, Protein transport",
author = "Frost, {Timothy S.} and Linan Jiang and Yitshak Zohar",
note = "Funding Information: ACKNOWLEDGMENT This project was supported by the Arizona Biomedical Research Commission through grant ABRC ADHS14-082983, and by a NASA Space Grant Undergraduate Internship.; 12th IEEE International Conference on Nano/Molecular Medicine and Engineering, NANOMED 2018 ; Conference date: 02-12-2018 Through 05-12-2018",
year = "2019",
month = feb,
day = "13",
doi = "10.1109/NANOMED.2018.8641558",
language = "English (US)",
series = "IEEE International Conference on Nano/Molecular Medicine and Engineering, NANOMED",
publisher = "IEEE Computer Society",
pages = "27--30",
booktitle = "Proceedings of the 12th IEEE International Conference on Nano/Molecular Medicine and Engineering, NANOMED 2018",
}