Characterizing cognitive aging of recognition memory and related processes in animal models and in humans

Sara N. Burke, Lee Ryan, Carol A. Barnes

Research output: Contribution to journalArticle

43 Scopus citations

Abstract

Analyses of complex behaviors across the lifespan of animals can reveal the brain regions that are impacted by the normal aging process, thereby, elucidating potential therapeutic targets. Recent data from rats, monkeys, and humans converge, all indicating that recognition memory and complex visual perception are impaired in advanced age. These cognitive processes are also disrupted in animals with lesions of the perirhinal cortex, indicating that the the functional integrity of this structure is disrupted in old age. This current review summarizes these data, and highlights current methodologies for assessing perirhinal cortex-dependent behaviors across the lifespan.

Original languageEnglish (US)
Article numberArticle 15
JournalFrontiers in Aging Neuroscience
Volume4
Issue numberSEP
DOIs
StatePublished - Dec 10 2012

Keywords

  • Medial temporal lobe
  • Monkey
  • Perception
  • Perirhinal cortex
  • Rat

ASJC Scopus subject areas

  • Aging
  • Cognitive Neuroscience

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