Charge Injection Device (CID) array detectors are well suited for the direct imaging with x- ray and particle beams. In common with CCD detectors, CID arrays have been shown to have good spatial resolution and broad spectral response in the visible range. In addition, CID imagers offer unique architectural features which may be particularly applicable to x-ray and particle beams, including exceptionally large pixel charge capacity, non-destructive pixel readout, and random pixel addressibility. These can dramatically extend the dynamic range, eliminate blooming effects, allow monitoring and dynamic adaptation of application exposure in real-time, improve signal-to-noise by repeated readout and permit the readout of small pixel sub-arrays at exceptionally fast rates. In addition CIDs possess extremely good radiation tolerance. Preliminary results of x-ray measurements with CIDs are presented along with a discussion of potential applications utilizing their unique features.