Chemical characterization of murine Ia alloantigens determined by the I-E/I-C subregions of the H-2 complex

J. Silver, W. A. Russell, B. L. Reis, J. A. Frelinger

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

Alloantisera directed against the alloantigens determined by the I-E and I-C subregions of the murine major histocompatibility complex precipitate two components that have molecular weights of 35,000 and 29,000. These components, when analyzed by partial NH2-terminal sequencing, show no homology to two components of similar size determined by the I-A subregion. However, the large chain determined by the murine I-E and/or I-C subregion is homologous to the large chain of the human HLA-D region alloantigen, although the small chains isolated from these two species do not display any such homology.

Original languageEnglish (US)
Pages (from-to)5131-5134
Number of pages4
JournalProceedings of the National Academy of Sciences of the United States of America
Volume74
Issue number11
DOIs
StatePublished - Jan 1 1977
Externally publishedYes

ASJC Scopus subject areas

  • General

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