Chemical characterization of murine Ia alloantigens determined by the I-E/I-C subregions of the H-2 complex

J. Silver, W. A. Russell, B. L. Reis, Jeffrey A Frelinger

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30 Citations (Scopus)

Abstract

Alloantisera directed against the alloantigens determined by the I-E and I-C subregions of the murine major histocompatibility complex precipitate two components that have molecular weights of 35,000 and 29,000. These components, when analyzed by partial NH2-terminal sequencing, show no homology to two components of similar size determined by the I-A subregion. However, the large chain determined by the murine I-E and/or I-C subregion is homologous to the large chain of the human HLA-D region alloantigen, although the small chains isolated from these two species do not display any such homology.

Original languageEnglish (US)
Pages (from-to)5131-5134
Number of pages4
JournalProceedings of the National Academy of Sciences of the United States of America
Volume74
Issue number11
StatePublished - 1977
Externally publishedYes

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Isoantigens
HLA-D Antigens
Major Histocompatibility Complex
Molecular Weight

ASJC Scopus subject areas

  • General
  • Genetics

Cite this

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abstract = "Alloantisera directed against the alloantigens determined by the I-E and I-C subregions of the murine major histocompatibility complex precipitate two components that have molecular weights of 35,000 and 29,000. These components, when analyzed by partial NH2-terminal sequencing, show no homology to two components of similar size determined by the I-A subregion. However, the large chain determined by the murine I-E and/or I-C subregion is homologous to the large chain of the human HLA-D region alloantigen, although the small chains isolated from these two species do not display any such homology.",
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language = "English (US)",
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pages = "5131--5134",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
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T1 - Chemical characterization of murine Ia alloantigens determined by the I-E/I-C subregions of the H-2 complex

AU - Silver, J.

AU - Russell, W. A.

AU - Reis, B. L.

AU - Frelinger, Jeffrey A

PY - 1977

Y1 - 1977

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AB - Alloantisera directed against the alloantigens determined by the I-E and I-C subregions of the murine major histocompatibility complex precipitate two components that have molecular weights of 35,000 and 29,000. These components, when analyzed by partial NH2-terminal sequencing, show no homology to two components of similar size determined by the I-A subregion. However, the large chain determined by the murine I-E and/or I-C subregion is homologous to the large chain of the human HLA-D region alloantigen, although the small chains isolated from these two species do not display any such homology.

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