Chemistry, Pharmacology, Antiarrhythmic Efficacy and Adverse Effects of Tocainide Hydrochloride, An Orally Active Structural Analog of Lidocaine

Joseph S. Alpert, Charles I. Haffajee, Michael D. Young

Research output: Contribution to journalArticle

5 Scopus citations


Tocainide is an orally effective antiarrhythmic agent, structurally and pharmacologically similar to lidocaine. It appears to be free of marked negative hemodynamic or electrophysiologic effects in patients with heart disease, despite a high frequency of minor and often transient central nervous system and gastrointestinal side effects. Tocainide is effective in suppressing ventricular arrhythmias in a variety of settings. This agent may be a useful addition to our antiarrhythmic armamentarium. 1983 Pharmacotherapy Publications Inc.

Original languageEnglish (US)
Pages (from-to)316-322
Number of pages7
JournalPharmacotherapy: The Journal of Human Pharmacology and Drug Therapy
Issue number6
StatePublished - Jan 1 1983


ASJC Scopus subject areas

  • Pharmacology (medical)

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