Chemoprevention of human skin cancer

Research output: Contribution to journalReview article

94 Scopus citations

Abstract

The incidence of skin cancer has been rising in recent years with significant effects on public health. Primary prevention has proven inadequate in impacting the incidence of skin cancer, thus stimulating the development of chemopreventive strategies. The majority of skin cancer chemoprevention studies focus on occurrence of new nonmelanoma skin cancers (NMSC) in individuals with a previous NMSC, or on reduction in the number of premalignant skin lesions such as actinic keratoses (AK). Dysplastic nevi, a likely precursor of melanoma, are also potential targets for chemoprevention strategies. Premalignant lesions are especially attractive as endpoints since they are more common than frank cancer, resulting in reduced sample size, length, and cost of clinical trials. Development of new agents that affect the pathogenesis of skin cancer will be discussed, from elucidation of molecular targets to implementation of trials designed to determine the effects of chemopreventive interventions on human skin cancer.

Original languageEnglish (US)
Pages (from-to)269-285
Number of pages17
JournalCritical Reviews in Oncology/Hematology
Volume41
Issue number3
DOIs
StatePublished - Mar 19 2002

Keywords

  • Actinic keratosis (AK)
  • Chemoprevention
  • Chemoprevention agents
  • Nonmelanoma skin cancer (NMSC)

ASJC Scopus subject areas

  • Hematology
  • Oncology

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